Results 31 to 40 of about 182,543 (292)

Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation. [PDF]

PLoS ONE, 2016
Electrolysis, electrochemotherapy with reversible electroporation, nanosecond pulsed electric fields and irreversible electroporation are valuable non-thermal electricity based tissue ablation technologies. This paper reports results from the first large
Michael K Stehling, Enric Guenther, Paul Mikus, Nina Klein, Liel Rubinsky, Boris Rubinsky   +5 more
doaj   +1 more source

Technological and theoretical aspects for testing electroporation on liposomes [PDF]

, 2017
Recently, the use of nanometer liposomes as nanocarriers in drug delivery systems mediated by nanoelectroporation has been proposed. This technique takes advantage of the possibility of simultaneously electroporating liposomes and cell membrane with 10 ...
Apollonio, Francesca, Denzi, Agnese, Esposito, Gianluca, Liberti, Micaela, Mir, Lluis M., Valle, Elena Della   +5 more
core   +3 more sources

Characterization of Experimentally Observed Complex Interplay between Pulse Duration, Electrical Field Strength, and Cell Orientation on Electroporation Outcome Using a Time-Dependent Nonlinear Numerical Model

Biomolecules, 2023
Electroporation is a biophysical phenomenon involving an increase in cell membrane permeability to molecules after a high-pulsed electric field is applied to the tissue.
Maria Scuderi, Janja Dermol-Černe, Tina Batista Napotnik, Sebastien Chaigne, Olivier Bernus, David Benoist, Daniel C. Sigg, Lea Rems, Damijan Miklavčič   +8 more
doaj   +1 more source

Modelling single cell electroporation with bipolar pulse parameters and dynamic pore radii [PDF]

, 2010
We develop a model of single spherical cell electroporation and simulate spatial and temporal aspects of the transmembrane potential and pore radii as an effect of any form of applied electric field.
Cree, Michael J., Gaynor, Paul, Talele, Sadhana, van Ekeran, Jethro   +3 more
core   +2 more sources

Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]

, 2012
Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Edward Wong, Ling Gu, Mathew Ficinski, Samarendra Mohanty, Samarendra Mohanty, Shivaranjani Shivalingaiah   +5 more
core   +2 more sources

Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system

BMC Biotechnology, 2023
Background Porcine fetal fibroblasts (PFFs) are important donor cells for generating genetically modified pigs, but the transfection efficiencies of PFFs are often unsatisfactory especially when large-size vectors are to be delivered.
Weiwei Liu, Xiaoguo Wang, Ruirong Liu, Yaya Liao, Zhiwei Peng, Haoyun Jiang, Qiqi Jing, Yuyun Xing   +7 more
doaj   +1 more source

Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma. [PDF]

, 2020
PurposeTumors with low frequencies of checkpoint positive tumor-infiltrating lymphocytes (cpTIL) have a low likelihood of response to PD-1 blockade.
Algazi, Alain P, Andtbacka, Robert HI, Arlauckas, Sean P, Ballesteros-Merino, Carmen, Bannavong, Donna, Bhatia, Shailender, Bifulco, Carlos, Browning, Erica, Canton, David A, Daud, Adil I, Fong, Lawrence, Fox, Bernard A, Francisco, Murray, Gargosky, Sharron, Garris, Christopher, Hermiz, Reneta, Le, Mai, Levine, Lauren P, Oglesby, Arielle, Pierce, Robert, Pittet, Mikael J, Rosenblum, Michael D, Tsai, Katy K, Twitty, Christopher G   +23 more
core   +2 more sources

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells [PDF]

, 2020
Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable.
Bultynck, Geert, De Bock, Marijke, De Smet, Maarten, Decrock, Elke, Delvaeye, Tinneke, Descamps, Benedicte, Hoorelbeke, Delphine, Krysko, Dmitri, Leybaert, Luc, Van Haver, Valérie, Vanhove, Christian   +10 more
core   +1 more source

Prostate cancer treatment with Irreversible Electroporation (IRE): Safety, efficacy and clinical experience in 471 treatments. [PDF]

, 2019
BackgroundIrreversible Electroporation (IRE) is a novel image-guided tissue ablation technology that induces cell death via very short but strong pulsed electric fields.
Guenther, E, Klein, N, Rubinsky, B, Schlosser, C, Stehling, MK, Weil, S, Zapf, S   +6 more
core   +2 more sources

Analysis of the Electric Field-Dependent Current During Electroporation Pulses

IEEE Access, 2020
When delivered across a cell, certain pulsed electric fields can cause an increase in the cell membrane permeability through a biophysical process known as electroporation.
Yanpeng Lv, Xian Cheng, Shuo Chen, Hongmei Liu, Yilin Wang, Chenguo Yao, Boris Rubinsky   +6 more
doaj   +1 more source