Results 41 to 50 of about 12,750 (179)
Frontiers in Neuroscience, 2021 Photocoagulation is used for the treatment of retinal ischemic disease. However, due to the invasive nature of photocoagulation and variety of melanin concentrations between individuals, it is challenging to avoid damaging the adjacent photoreceptors and
Zhexuan Wang +8 more
doaj +1 more source
Clinical manifestations of dual‐gene variants in retinitis pigmentosa
Acta Ophthalmologica, EarlyView.Abstract Purpose Retinitis pigmentosa (RP) is an inherited retinal disease (IRD), whereby each affected individual typically harbours pathogenic variants in a single causative gene, yet the disorder exhibits marked genetic heterogeneity, with more than 100 genes reported to underlie RP.
Lasse Wolfram +11 more
wiley +1 more source
Retinal dystrophies simulating geographic atrophy: A diagnostic challenge
Acta Ophthalmologica, EarlyView.Abstract Geographic atrophy (GA) is the chronic loss of retinal pigment epithelium, photoreceptors and choriocapillaris, marking the dry late stage of age‐related macular degeneration (AMD). GA prevalence is expected to rise in the upcoming decades. Advanced GA leads to central scotomas, reducing visual acuity and quality of life, potentially resulting
Johanna M. Colijn +3 more
wiley +1 more source
Marine DrugsThe management of vision-threatening retinal diseases remains challenging due to the lack of an effective drug delivery system. Encapsulated cell therapy (ECT) offers a promising approach for the continuous delivery of therapeutic agents without the need
Tingyu Hu +6 more
doaj +1 more source
CORRECTION OF HYPERTENSIVE NEURORETINOPATHY BY DIMETHYLAMINOETHANOL DERIVATIVE 7-16 IN EXPERIMENT
Кубанский научный медицинский вестник, 2018 Aim. Increase of efficiency of pharmacological correction of hypertensive neuroretinopathy using a new dimethylaminoethanol (DMAE) derivative 7-16.Materials and methods.
A. A. PERESYPKINA +3 more
doaj +1 more source
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background The lack of validated and sensitive clinical endpoints remains a major challenge in the design of gene therapy trials for inherited retinal dystrophies (IRDs). This prospective longitudinal cohort study describes the natural disease progression of IRDs caused by pathogenic mutations in the Crumbs homologue 1 (CRB1) gene, and ...
Jessica S. Karuntu +15 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyPurposeExtraocular electrical stimulation is known to provide neuroprotection for retinal cells in retinal and optic nerve diseases. Currently, the treatment approach requires patients to set up extraocular electrodes and stimulate potentially weekly due
Carla J. Abbott +21 more
doaj +1 more source
A case study of Usher’s syndrome [PDF]
Perspectives In Medical Research, 2018 Usher’s syndrome is the most common condition that affects both hearing and vision. The major symptoms of Usher’s syndrome are hearing loss and an eye disorder called retinitis pigmentosa, or RP.
Kapil S1 , Arvind R2
doaj
Clinical Genetics, Volume 110, Issue 3, Page 336-346, September 2026.Opticus atrophy—Genetic testing with WES/WGS in 62 patients with optic atrophy provided a genetic diagnosis in 21 patients (33.9%). 42.9% of these involved non‐OPA1 genes, including WFS1, ACO2, NR2F1, UCHL1, CACNA1F, and COQ2, where the genetic diagnosis prompted additional clinical evaluation, surveillance, or therapeutic intervention.
Katrine M. Johannesen +9 more
wiley +1 more source
Veterinary Ophthalmology, Volume 29, Issue 5, September 2026.ABSTRACT Objective This study aimed to evaluate pre‐ and postoperative changes in the iridocorneal angle, ciliary cleft (CC), and ciliary muscle (CM) in canine eyes with intumescent cataracts using ultrasound biomicroscopy (UBM), with comparative reference to normal and non‐intumescent cataractous eyes.
Jiyi Hwang +7 more
wiley +1 more source