Results 61 to 70 of about 28,602 (306)

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

Liposome-Mediated Delivery Improves the Efficacy of Lisosan G against Retinopathy in Diabetic Mice

Cells, 2023
Nutraceuticals are natural substances whose anti-oxidant and anti-inflammatory properties may be used to treat retinal pathologies. Their efficacy is limited by poor bioavailability, which could be improved using nanocarriers. Lisosan G (LG), a fermented
Rosario Amato, Alberto Melecchi, Laura Pucci, Alessio Canovai, Silvia Marracci, Maurizio Cammalleri, Massimo Dal Monte, Carla Caddeo, Giovanni Casini   +8 more
doaj   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Platelet-activating factor receptor (PAFR) regulates neuronal maturation and synaptic transmission during postnatal retinal development

Frontiers in Cellular Neuroscience
IntroductionPlatelet-activating factor (PAF), PAF receptor (PAFR), and PAF- synthesis/degradation systems are involved in essential CNS processes such as neuroblast proliferation, differentiation, migration, and synaptic modulation.
Barbara Dalmaso, Andre Mauricio Passos Liber, Andre Mauricio Passos Liber, Dora Fix Ventura, Sonia Jancar, Carolina Beltrame Del Debbio   +5 more
doaj   +1 more source

A nonhuman primate model of inherited retinal disease. [PDF]

, 2019
Inherited retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmentosa and cone dystrophy affecting approximately 1 in 3500 and 1 in 10,000 individuals, respectively.
Artemyev, Nikolai O, Boyd, Kimberly, Cameron, Ashley, Chen, Rui, Davis, Sarah, Garzel, Laura, Gopalakrishna, Kota N, Harris, R Alan, Huang, Yijun, Kim, Soohyun, Li, Yumei, Liang, Qingnan, Moshiri, Ala, Murphy, Christopher J, Pomerantz, Ori, Raveendran, Muthuswamy, Roberts, Jeffrey, Rogers, Jeffrey, Stout, J Timothy, Thomasy, Sara M, Wang, Jun, Yiu, Glenn   +21 more
core  

Visual function assessment in patients with cone dystrophy [PDF]

, 2003
PURPOSE: To evaluate visual function by full-field electroretinography (ERG) and visual acuity in patients with cone dystrophy. METHODS: 23 (7 male and 16 female) patients with suspicion of cone dystrophy were evaluated at the Clinical Electrophysiology ...
Berezovsky, Adriana, Sacai, Paula Yuri, Salomão, Solange Rios, Sato, Marta   +3 more
core   +2 more sources

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Retinal Architecture in ​\u3cem\u3eRGS9-\u3c/em\u3e and ​\u3cem\u3eR9AP\u3c/em\u3e-Associated Retinal Dysfunction (Bradyopsia) [PDF]

, 2015
Purpose To characterize photoreceptor structure and mosaic integrity in subjects with RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy ...
Ba-Abbad, Rola, Carroll, Joseph, Cooper, Robert F., Dubis, Adam M., Dubra, Alfredo, Michaelides, Michel, Moore, Anthony T., Strauss, Rupert W., Webster, Andrew R.   +8 more
core   +1 more source

Syntaxin 3B Mediates Light‐Dependent Interactions with STXBP1 and Arrestin 4: Distinct Roles in Rods and Cones

Advanced Science, EarlyView.
The present study investigates a cone‐specific STX3 knockout model, displaying a complete loss of cone function, a later onset reduction in rod function, and photoreceptor cell death. A cone‐specific depletion of STXBP1 and ARR4 could be observed in this model.
Lars Tebbe, Larissa Ikelle, Mustafa S. Makia, Mashal Kakakhel, Muayyad R. Al‐Ubaidi, Muna I. Naash   +5 more
wiley   +1 more source

Bilateral phacoemulsification and intraocular lens implantation in a pet rabbit with cataracts

Open Veterinary Journal
Background: The occurrence of cataracts in rabbits is a common reason for consultation in veterinary ophthalmology. Case Description: A 6-year-old female Lop rabbit (Oryctolagus cuniculus) was referred with a 3-month history of bilateral cataracts ...
Frederic Goulle, Pauline Bodin, Heloïse Cousin, Morgane Prieto, Charles Cassagnes   +4 more
doaj   +1 more source