Results 71 to 80 of about 20,458 (217)

Modern Methods for the Diagnosis of Morphological and Functional Features of the Retina in Dysbinocular and Anisometropic Amblyopia

Oftalʹmologiâ, 2022
Child health is a global health priority. Anomalies of refraction, complicated by amblyopia and squint, occupy one of the leading places in the pathology of the visual system of children.
R. R. Khubieva, E. P. Tarutta
doaj   +1 more source

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan, Ezgi Erbasan, Fulya Erendor, Salih Sanlioglu   +3 more
wiley   +1 more source

Non-invasive electroretinography

Biomedicine & Pharmacotherapy, 2006
Electroretinographic (ERG) investigations are conventionally performed by using corneal or conjunctival recording electrodes. Both types have to be placed in contact with the eye, resulting invasive and providing discomfort for the patient. This paper presents a simple technique to detect ERG potentials non-invasively.
CARPI, FEDERICO, Tomei, F.
openaire   +3 more sources

Bioactive Glial-Derived Neurotrophic Factor from a Safe Injectable Collagen–Alginate Composite Gel Rescues Retinal Photoreceptors from Retinal Degeneration in Rabbits

Marine Drugs
The management of vision-threatening retinal diseases remains challenging due to the lack of an effective drug delivery system. Encapsulated cell therapy (ECT) offers a promising approach for the continuous delivery of therapeutic agents without the need
Tingyu Hu, Ting Zhou, Rajesh Kumar Goit, Ka Cheung Tam, Yau Kei Chan, Wai-Ching Lam, Amy Cheuk Yin Lo   +6 more
doaj   +1 more source

Loss of Kv8.2 in the Mouse Retina Is Associated With Altered One‐Carbon Metabolism

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Kv8.2 knockout mice, a model of KCNV2 retinopathy, exhibit impaired potassium homeostasis in photoreceptors and slowly progressive rod degeneration. To investigate metabolic adaptations accompanying this dysfunction, untargeted metabolomic profiling was performed on mouse retinas.
Karina Kruth, Sheila A. Baker
wiley   +1 more source

Evaluation of earlier versus later dietary management in long-chain 3-hydroxyacyl-CoA dehydrogenase or mitochondrial trifunctional protein deficiency::a systematic review [PDF]

, 2019
Background: Mitochondrial trifunctional protein (MTP) and long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiencies are rare fatty acid β-oxidation disorders. Without dietary management the conditions are life-threatening. We conducted a systematic
Clarke, Aileen, Connock, Martin, Fraser, Hannah, Geppert, Julia, Johnson, Rebecca, Johnson, Samantha, Stinton, Christopher, Taylor-Phillips, Sian   +7 more
core   +2 more sources

Chronic electrical stimulation with a peripheral suprachoroidal retinal implant: a preclinical safety study of neuroprotective stimulation

Frontiers in Cell and Developmental Biology
PurposeExtraocular electrical stimulation is known to provide neuroprotection for retinal cells in retinal and optic nerve diseases. Currently, the treatment approach requires patients to set up extraocular electrodes and stimulate potentially weekly due
Carla J. Abbott, Carla J. Abbott, Penelope J. Allen, Penelope J. Allen, Penelope J. Allen, Chris E. Williams, Chris E. Williams, Richard A. Williams, Richard A. Williams, Stephanie B. Epp, Owen Burns, Ross Thomas, Mark Harrison, Patrick C. Thien, Patrick C. Thien, Alexia Saunders, Ceara McGowan, Caitlin Sloan, Chi D. Luu, Chi D. Luu, David A. X. Nayagam, David A. X. Nayagam   +21 more
doaj   +1 more source

A case study of Usher’s syndrome [PDF]

Perspectives In Medical Research, 2018
Usher’s syndrome is the most common condition that affects both hearing and vision. The major symptoms of Usher’s syndrome are hearing loss and an eye disorder called retinitis pigmentosa, or RP.
Kapil S1 , Arvind R2
doaj  

Dual‐Target ROS‐Driven Spatiotemporal Senolysis for Vascular Repair and Immune Microenvironment Reprogramming in the Treatment of Ocular Fundus Neovascularization

Advanced Science, Volume 13, Issue 16, 18 March 2026.
We developed a senolytic approach using procyanidin C1 (PCC1)‐loaded platform, a clinically established and safe hyaluronic acid‐based scaffold, to selectively eliminate senescent endothelial and microglial cells. This dual‐targeting strategy significantly suppresses pathological neovascularization and promotes vascular repair, presenting a safe and ...
Yali Zhou, Tianxing Chen, Peiyu Liu, Kangjia Lv, Yifan Wang, Xiaoqian Wang, Junwei Fang, Chong Chen, Zhaoyang Wang, Fang Wei, Xun Xu   +10 more
wiley   +1 more source

Visual acuity and full-field electroretinography in patients with Usher's syndrome [PDF]

, 2005
PURPOSE: Usher's syndrome (US) is a group of genetically distinct autossomal conditions, characterized by sensorineural hearing loss accompanied by a retinal dystrophy indistinguishable from retinitis pigmentosa (RP).
Berezovsky, Adriana, Fantini, Sérgio Costa, Mendieta, Luana, Pereira, Josenilson Martins, Sacai, Paula Yuri, Salomão, Solange Rios   +5 more
core   +4 more sources