Results 61 to 70 of about 16,832 (328)
Design, synthesis and pharmacological profile of (−)-verbenone hydrazones
Open Chemistry, 2020 A series of novel (−)-verbenone hydrazones was designed and synthesized via condensation of terpenoid with hydrazides derived from phenoxyacetic acid.
Nesterkina Mariia +2 more
doaj +1 more source
Neurosteroids and Seizure Activity
Frontiers in Endocrinology, 2020 Still circa 25% to 30% of patients with epilepsy cannot be efficiently controlled with available antiepileptic drugs so newer pharmacological treatment options have been continuously searched for.
Barbara Miziak +2 more
doaj +1 more source
Is there a potential of misuse for Magnolia officinalis compounds/metabolites? [PDF]
, 2017 © 2017 John Wiley & Sons, Ltd.Objective: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers ...
Alexeev +32 more
core +3 more sources
The Anatomical Record, EarlyView.Abstract Dicynodonts (Anomodontia: Dicynodontia) were one of the main groups of terrestrial tetrapods in Permian and Triassic faunas. In Brazil, the genus Dinodontosaurus is one of the most common tetrapod taxon in the Triassic Santa Maria Supersequence. This genus has a complex taxonomic history and is represented in the Triassic of both Argentina and
Julia Lara Rodrigues de Souza +5 more
wiley +1 more source
Novel derivatives of phthalimide with potent anticonvulsant activity in PTZ and MES seizure models [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Phthalimide-based derivatives have anticonvulsant activity like as phenytoin by inhibition of sodium channel. In our previously research we mentioned about some phthalimide derivatives as potent anticonvulsant agents. Materials and Methods:
Asghar Davood +7 more
doaj +1 more source
Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2′-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice [PDF]
, 2016 We evaluated the effects of ACEA (selective cannabinoid (CB)1 receptor agonist), WIN 55,212-2 mesylate (WIN; non-selective CB1 and CB2 receptor agonist) and N-palmitoylethanolamine (PEA; an endogenous fatty acid of ethanolamide) in DBA/2 mice, a genetic ...
AVAGLIANO, CARMEN +7 more
core +1 more source
Zur Einführung der „Schocktherapien" und Leukotomie in Deutschland [PDF]
, 2020 Die Geschichte der „Schocktherapien“ und Leukotomie in Deutschland war lange ein vernachlässigtes Kapitel der Psychiatriegeschichte. Vorurteile behinderten über Jahre hinweg eine detaillierte Aufarbeitung.
Rzesnitzek, Lara
core +1 more source
The Anatomical Record, EarlyView.Abstract The study of morphological evolution is fundamentally tied to ontogeny, yet studies of these heterochronic processes in the fossil record are rare. Fossils belonging to an ontogenetic series are difficult to assign to an ontogenetic stage due to inconsistent proxies for skeletal ages, challenging to taxonomically assign due to morphological ...
Erika R. Goldsmith, Michelle R. Stocker
wiley +1 more source
Electroshock Induced Seizures in Adult C. elegans
Bio-Protocol, 2017 The nematode Caenorhabditis elegans is a useful model organism for dissecting molecular mechanisms of neurological diseases. While hermaphrodite C. elegans contains only 302 neurons, the conserved homologous neurotransmitters, simpler neuronal circuitry,
Monica Risley +2 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims The aim of this study was to introduce a new assessment method for pharmacy students' real‐life competence in reviewing medications after obligatory advanced‐level practical internship in Finland. Methods The new medication review (MR) competence assessment method consisted of (1) a self‐assessment by pharmacy students and (2) a performance ...
Katja Leiman +5 more
wiley +1 more source