Results 101 to 110 of about 153,863 (245)

Extending the Range of Sizes of Monodisperse Core‐Shell Hydrogel Capsules from Composite Jet Breakup by Combined Electrical and Mechanical Actuation

open access: yesAdvanced Science, EarlyView.
We present a microfluidic approach combining electrical and mechanical actuation to improve control over liquid jet breakup and droplet formation. By adjusting excitation frequency and applying an electric field, coalescence is reduced and droplet uniformity is enhanced.
Lucas Suire   +3 more
wiley   +1 more source

Coaxial helium electrospray for single-particle imaging at X-ray free electron lasers. [PDF]

open access: yesJ Synchrotron Radiat
Rafie-Zinedine S   +3 more
europepmc   +1 more source

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

open access: yesAdvanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra   +9 more
wiley   +1 more source

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators

open access: yesAdvanced Science, EarlyView.
A computational approach to identify and characterize ligandable binding pockets on E3 ligases is presented. As a validation case, the first low‐micromolar small moleculesthat bind to the FBW7 E3 ligase are identified and confirmed to bind at the intended site.
Míriam Martínez‐Cartró   +13 more
wiley   +1 more source

Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat

open access: yesAdvanced Science, EarlyView.
Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang   +17 more
wiley   +1 more source

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