Results 171 to 180 of about 153,863 (245)

Hinge‐Like Mechanochromic Mechanophores Based on [2.2]Paracyclophane

open access: yesAngewandte Chemie, EarlyView.
Hinge‐like supramolecular mechanophores utilizing [2.2]paracyclophane have been developed. In the force‐free state, the rigid [2.2]paracyclophane forces two luminophores into proximity, leading to excimer‐dominant photoluminescence. Stretching the polyurethane films into which the mechanophores are covalently incorporated results in the structures of ...
Shohei Shimizu   +3 more
wiley   +2 more sources

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Deleting Col6a3 exon 3 by CRISPR in mice results in centralized nuclei consistent with a myopathy phenotype mimicking collagen VI‐associated human disease Abstract Background Most mutations in the COL6A3 gene lead to collagen VI‐related myopathies. This is due to a reduced expression or mislocalization of the COL6A3 protein.
Michel ElChoueiry   +12 more
wiley   +1 more source

Advances on Albumin‐Based Carriers for Anticancer Drug Delivery

open access: yesAdvanced NanoBiomed Research, EarlyView.
This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou   +4 more
wiley   +1 more source

Real‐Time Eco–AI, Electrophoresis‐Correlative Data‐Dependent Acquisition with AI‐Based Data Processing Broadens Access to Single‐Cell Mass Spectrometry Proteomics

open access: yesAngewandte Chemie, EarlyView.
An affordable single‐cell proteomics workflow combines capillary electrophoresis, real‐time ion sorting, and AI‐aided spectral deconvolution to profile early Xenopus embryonic cells. Despite using a legacy Orbitrap, this strategy matches or exceeds the sensitivity of modern instruments, uncovering proteome dynamics at sub‐nanogram scale.
Bowen Shen, Fei Zhou, Peter Nemes
wiley   +2 more sources

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