Results 181 to 190 of about 153,863 (245)

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

Flexibility‐Aided Orientational Self‐Sorting and Transformations of Bioactive Homochiral Cuboctahedron Pd12L16

Angewandte Chemie, EarlyView.
Mimicking concave morphologies found in nature, we have introduced flexible, unsymmetric, tridentate ligand (L) which undergoes coordination self‐assembly into highly organized chiral Pd6L8 or Pd12L16 cages that can undergo interspecific transformations. The cages, being based on natural amphiphilic transport molecules, mediate high cellular uptake and
Subhasis Chattopadhyay, Robin Durník, Anniina Kiesilä, Elina Kalenius, Juha M. Linnanto, Pavel Babica, Jan Kuta, Radek Marek, Ondřej Jurček   +8 more
wiley   +2 more sources

The Dark Metabolome/Lipidome and In-Source Fragmentation. [PDF]

Anal Sci Adv
Uritboonthai W, Hoang L, Aisporna A, Giera M, Siuzdak G.   +4 more
europepmc   +1 more source

High-performance liquid chromatography of selenium compounds utilizing perfluorinated carboxylic acid ion-pairing agents and inductively coupled plasma and electrospray ionization mass spectrometric detection

, 2000
Mihály Kotrebai, Julian F. Tyson, Eric Block, Peter C. Uden   +3 more
openalex   +2 more sources

De Novo Designed β‐Hairpin Peptides Mimicking the Copper‐Binding Histidine Brace Motif of Lytic Polysaccharide Monooxygenases

Angewandte Chemie, EarlyView.
In this work, the copper‐binding histidine brace (His‐brace) motif found in lytic polysaccharide monooxygenase (LPMO) enzymes was engineered in de novo designed peptides that fold as β‐hairpins (HisPins). Cu‐HisPins complexes showed LPMO‐like activity, including light‐stimulated melanin‐mediated oxidative cellulose degradation.
Enrico Falcone, Rosemary Tomey, Emma Turley, David Cannella, David Robinson, Luisa Ciano   +5 more
wiley   +2 more sources

Coupling Capillary Electrophoresis With a Shifted Inlet Potential High-Resolution Ion Mobility Spectrometer. [PDF]

Electrophoresis
Welters K, Thoben C, Raddatz CR, Schlottmann F, Zimmermann S, Belder D.   +5 more
europepmc   +1 more source

Antibody-Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
Fiala J, Schuster D, Heck AJR.
europepmc   +1 more source

Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes. [PDF]

Pharmaceutics
Calemi DBA, Godoi AB, Minuti G, Neto FC, Hispagnol GF, Pilon AC, Costa JL, Hyslop S, Antunes NJ.   +8 more
europepmc   +1 more source

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source