Results 91 to 100 of about 119,736 (261)
Advanced Science, EarlyView.The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong +13 more
wiley +1 more source
Hydrogen Atom Transfer Induces Photodegradation in Carbonyl‐Based Multi‐Resonance TADF Emitters
Angewandte Chemie, EarlyView.Boosting triplet harvesting in N/C═O MR‐TADF emitters unexpectedly induces rapid photodegradation under oxygen‐free conditions. Spectroscopic studies reveal that triplet excited states trigger hydrogen‐atom transfer from solvent to the carbonyl unit, driven by triplet energetics and hydrogen electrophilicity.
Changfeng Si +4 more
wiley +2 more sources
Journal of Pharmaceutical AnalysisLiquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS) is a widely utilized technique for in vivo pharmaceutical analysis. Ionization interference within electrospray ion source, occurring between drugs and metabolites, can ...
Fulin Jiang +8 more
doaj +1 more source
Advanced Science, EarlyView.Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan +17 more
wiley +1 more source
Advanced Science, EarlyView.Non‐ideal redox electrolytes still govern the Nernstian behavior of electrode potentials in aqueous organic redox flow batteries under operation. We utilized this effect to analytically predict two scenarios of battery performance degradation. ABSTRACT Aqueous organic redox flow batteries (AORFBs) enhance the sustainability of battery energy storage ...
Faudillah Alhumairah +9 more
wiley +1 more source
Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis
Animal Models and Experimental Medicine, EarlyView.This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding +10 more
wiley +1 more source
Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes
Advanced NanoBiomed Research, EarlyView.Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr +9 more
wiley +1 more source
Ionization Process and Electrospray.
Journal of the Mass Spectrometry Society of Japan, 1996 Scientist observed natural phenomena and found the existence of ions more than 100 years ago. When the historical background of electrospray was surveyed from the view point of the ionization technique, the origin started by the awareness of the charged drops in nature. Our earth is positively charged and abounds in the positive ion.
openaire +2 more sources
Method validation of clonidine hydrochloride in human plasma by LC-MS technique
Pharmaceutical and Biomedical Research, 2015 A simple and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been evaluated for the assignment of clonidine hydrochloride in human plasma.
Hossein Danafar
doaj