Results 191 to 200 of about 142,148 (337)

Altering 15‐Lipoxygenases to 18‐Lipoxygenases and Their Application to the Production of 5,18‐Dihydroxyeicosapentaenoic Acids

open access: yesBiotechnology and Bioengineering, EarlyView.
15R‐ and 15S‐lipoxygenases (15R‐ and 15S‐LOXs) were engineered into 18R‐ and 18S‐LOXs, respectively. Escherichia coli expressing these enzymes converted eicosapentaenoic acid into 18R‐ and 18S‐hydroxyeicosapentaenoic acids (18R‐ and 18S‐HEPEs), respectively.
Jin Lee   +3 more
wiley   +1 more source

The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay

open access: yesChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022
The adipokine chemerin and the short peptide agonist chemerin‐9 activate two GPCRs: CMKLR1 and GPR1. Here, we established a nanoluciferase based binding assay to analyze differences in ligand binding. For GPR1, both ligands show high affinity and comparable binding.
Anne Sophie Czerniak   +3 more
wiley   +1 more source

Characterization of Anticancer Drug Protomers Using Electrospray Ionization and Ion Mobility Spectrometry-Mass Spectrometry. [PDF]

open access: yesJ Am Soc Mass Spectrom
Basuri P   +6 more
europepmc   +1 more source

Efficient One‐Step Production of 7S,17S‐ and 10S,17S‐Dihydroxydocosahexaenoic Acids by a Double‐Oxygenating 15S‐Lipoxygenase From Chlamydomonas incerta

open access: yesBiotechnology and Bioengineering, EarlyView.
Biotransformation pathway from polyunsaturated fatty acids into dihydroxy fatty acids as lipid mediators by Escherichia coli expressing Chlamydomonas incerta 15S‐lipoxygenase with double oxygenating activity. The 15S‐lipoxygenase was the most efficient for the simultaneous production of resolvin D5 (7S,17S‐dihydroxydocosahexaenoic acid, 7S,17S‐DiHDHA ...
Hyun‐Ah Park, Jin Lee, Deok‐Kun Oh
wiley   +1 more source

A Neutral and Stable Macrocyclic Mn(II) Complex for MRI Tumor Visualization

open access: yesChemMedChem, Volume 17, Issue 24, December 16, 2022., 2022
Research on contrast agents for magnetic resonance imaging has recently guided efforts toward paramagnetic Mn(II) and Fe(III) complexes as alternatives to the well‐established Gd(III)‐based agents regularly used in clinical settings.The new neutral Mn(II) complex MnDO2AMGly reported herein shows good relaxometric performance, no toxicity, and in vivo ...
Loredana Leone   +5 more
wiley   +1 more source

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