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Electrospray Ionization Mass Spectrometry of Oligonucleotides
Current Protocols in Nucleic Acid Chemistry, 2008AbstractBecause of the high molecular weights and thermal lability of biomolecules such as nucleic acids and protein, they can be difficult to analyze by mass spectrometry. Such analyses require a “soft” ionization method that is capable of generating intact molecular ions.
Colette M, Castleberry +2 more
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Electrospray ionization mass spectrometry of ginsenosides
Journal of Mass Spectrometry, 2002AbstractGinsenosides Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2 and F11 were studied systematically by electrospray ionization mass spectrometry in positive‐ and negative‐ion modes with a mobile‐phase additive, ammonium acetate. In general, ion sensitivities for the ginsenosides were greater in the negative‐ion mode, but more structural information on the ...
Xiu-Sheng, Miao +3 more
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Electrospray-ionization driven by dielectric polarization
Analytical and Bioanalytical Chemistry, 2008A non-conductive piezo ceramic plate has been used to induce an electric field to generate an electrospray as ionization method for mass spectrometric determination. This technique decreases the risk of undesired discharges, induced by high electric currents. The applicability of the technique is demonstrated and compared with a commercial electrospray
Michael, Schilling +2 more
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Generating Electrospray Ionization on Ballpoint Tips
Analytical Chemistry, 2016In this study, we report a simple and economical ballpoint electrospray ionization mass spectrometry (BP-ESI-MS) technique. This combines a small ballpoint tip with a syringe pump for the direct loading and ionization of various samples in different phases (including solution, semisolid, and solid) and allows for additional applications in surface ...
Baocheng, Ji +5 more
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Electrospray Ionization Using Wooden Tips
Analytical Chemistry, 2011Electrospray ionization (ESI) is a mass spectrometric technique widely used in various fields including chemistry, biology, medicine, pharmaceutical industry, clinical assessment, and forensic science. In this study, we report a simple and economical ESI-mass spectrometry (MS) technique, which makes use of disposable wooden tips (wooden toothpicks) for
Bin, Hu +3 more
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Oxidation of peptides during electrospray ionization
Rapid Communications in Mass Spectrometry, 1993Abstract [M+H+16] + ions were observed in the electrospray ionization mass spectra of several synthetic and maturally occurring peptides. Initial results have shown that the appearance of the modification is dependent on the field strength at the electrospray needle and the ...
K, Morand, G, Talbo, M, Mann
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Integration of electropreconcentration and electrospray ionization in a microchip
Journal of Chromatography A, 2018A microfluidic glass chip for performing sensitive mass spectrometry (MS) is developed by integrating nanochannel-based electropreconcentration with electrospray ionization (ESI). Cation analytes in acidic buffer conditions (∼pH 3) were preconcentrated at a micro-nano-microchannel junction where a positively charged polymer, polyE-323, is coated to ...
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Microfabrication of polydimethylsiloxane electrospray ionization emitters
Journal of Chromatography A, 2001Microfabricated polydimethylsiloxane (PDMS) emitters for electrospray ionization mass spectrometry (ESI-MS) were implemented as tips along the edge of the PDMS device by three methods which utilize soft lithography processes. These microfabrication methods for producing PDMS emitters as an integral part of a microfluidic device will facilitate ...
J S, Kim, D R, Knapp
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An Electrospray Ionization Source for Integration with Microfluidics
Analytical Chemistry, 2002We have demonstrated a new electrospray ionization (ESI) device incorporating a tip made from a shaped thin film, bonded to a microfluidic channel, and interfaced to a time-of-flight mass spectrometer (TOFMS). A triangular-shaped thin polymer tip was formed by lithography and etching.
Jun, Kameoka +5 more
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Secondary Electrospray Ionization
2014This chapter details the technique called extractive electrospray ionization (EESI) and describes its state-of-the-art developmental, mechanical and experimental aspects and shows its most important applications. EESI is a sensitive, matrix-tolerant secondary electrospray ionization technique, which is in the focus of ongoing investigations.
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