British Journal of Clinical Pharmacology, EarlyView.Aims The aim of this study is to evaluate the effects of multiple doses of esomeprazole, a strong proton pump inhibitor and acid‐reducing agent, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader.
Lana Tran +7 more
wiley +1 more source
Analysis of the dynamic metabolic changes during the ripening of wolfberry (<i>Lycium barbarum</i> L.) fruits by theta-nano-extractive electrospray ionization mass spectrometry. [PDF]
Food Chem XLiu Y +6 more
europepmc +1 more source
Development of a nalmefene formulation suitable for a community‐use auto‐injector
British Journal of Clinical Pharmacology, EarlyView.Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano +6 more
wiley +1 more source
Native mass spectrometry enabled by infrared matrix-assisted laser desorption electrospray ionization for rapid measurement of protein-ligand biophysical parameters. [PDF]
Anal Bioanal ChemAdepoju AA, Ghiladi RA, Muddiman DC.
europepmc +1 more source
Relationships among nitrous oxide exposure, neurological injury and biomarkers
British Journal of Clinical Pharmacology, EarlyView.Aims Recreational nitrous oxide (N2O) misuse is an increasing public health problem associated with functional cobalamin (B12) deficiency and severe neurological complications. Despite growing recognition of its harms, the dose–response relationship and clinical value of biomarkers remain unclear.
Laxna Bhujel +6 more
wiley +1 more source
Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real-Time Chemical Analysis. [PDF]
Mass Spectrom RevLuo X +5 more
europepmc +1 more source
Biopharmaceutics &Drug Disposition, EarlyView.Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula +4 more
wiley +1 more source
Evaluation of thermal desorption-electrospray ionization mass spectrometry for characterization of <i>Mycobacterium tuberculosis</i>: Comparison with MIRU-VNTR and whole-genome sequencing. [PDF]
J Mass Spectrom Adv Clin LabYang TY +7 more
europepmc +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Improving cell‐specific productivity remains a central objective in biopharmaceutical manufacturing. In this study, the effect of blue light illumination on IgG1‐producing CHO DP‐12 cells was systematically evaluated across batch, fed‐batch, and perfusion cultivations in controlled 3 L bioreactor systems.
Stefanie Föller +2 more
wiley +1 more source
Improvement of Electrospray Ionization Response Linearity and Quantification in Dissolved Organic Matter Using Synthetic Deuterated Internal Standards. [PDF]
Anal ChemCraig AJ +7 more
europepmc +1 more source