Rapid Determination of Several Biogenic Amines in Cold-Chain Fish Samples by Portable Ion Trap Mass Spectrometry with Nano-Electrospray Ionization. [PDF]
FoodsWu J +6 more
europepmc +1 more source
Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, EarlyView.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Identifying Key Metabolites in South African Medicinal Plants Using Dual Electrospray Ionization Metabolomics. [PDF]
Plants (Basel)Makhafola MA +7 more
europepmc +1 more source
Angewandte Chemie, EarlyView.Reversible protonation gates coumarin‐based overcrowded‐alkene molecular motors by dynamically reshaping their conjugation topology. This strategy enables efficient, near‐quantitative unidirectional photoisomerization from blue–green to red‐shifted visible light up to 600 nm, while preserving motor function and allowing orthogonal light, heat, and acid/
Jinghao Wang +2 more
wiley +2 more sources
Achieving Single-Cell Resolution via Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) on Different Platforms. [PDF]
Anal ChemColwell N +4 more
europepmc +1 more source
Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization
Angewandte Chemie, EarlyView.The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu +6 more
wiley +2 more sources
Click-and-Analyze: Automated Pinpoint Ambient Mass Spectrometry with Sheath-Flow Probe Electrospray Ionization. [PDF]
Mass Spectrom (Tokyo)Li L, Xie Q, Chen LC, Ninomiya S.
europepmc +1 more source
Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides
Angewandte Chemie, EarlyView.Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok +4 more
wiley +2 more sources
Intramolecularly Labeled Reference Standards of Sulfamethoxazole for Fragment-Specific Isotope Analysis by Electrospray Ionization Orbitrap Mass Spectrometry. [PDF]
J Am Soc Mass SpectromCanavan A, Dirr C, Elsner M.
europepmc +1 more source
Angewandte Chemie, EarlyView.Single‐atom growth from [Zr@Sb12]2− to [Zr@Sb13]3− disrupts the closed‐shell S2P6 superatomic configuration and markedly attenuates three‐dimensional (3D) aromaticity. Ultrafast spectroscopy further links stronger spherical aromaticity to slower excited‐state relaxation, establishing an atom‐resolved structure‐aromaticity‐dynamics relationship ...
Yun Zhang +7 more
wiley +2 more sources