Results 41 to 50 of about 149,784 (296)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Single-Cell Analysis and Its Applications by Surface Desorption Ambient Mass Spectrometry
Zhipu XuebaoAs the fundamental units of the structure and function of living organisms, cells perform the core functions of life activities. With the deepening research in life sciences, the importance of studies on cellular heterogeneity has become increasingly ...
Dan LIN +5 more
doaj +1 more source
Indonesian Journal of Chemistry, 2010 Semisynthesis of D6,7-Anhydroerythromycin-A was done by biomodification technique by addition of 0.2% INH into a culture fermentation of Saccharopolyspora erythraea ATCC 11635 in medium Hutchinson.
Khairan Khairan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
mSystems, 2021 The identification and accurate quantification of metabolites using electrospray ionization-mass spectrometry (ESI-MS) in hypersaline samples is a challenge due to matrix effects.
Chengdong Xu +16 more
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Influence of electrostatics upon electrospray with the intention of application to colloid thrusters [PDF]
, 2011 PhDA thorough experimental and theoretical characterization of the effect of electrostatics on the electrospray process, focusing particularly on the flow rate sensitivity to the applied potential difference (voltage), has been completed.
Ryan, Charles N., Ryan, Charles N
core
Merged electrospray ionization mass spectrometry [PDF]
, 2009 Ambient ionization allows the analysis of materials in their native environment without sample preparation by creating ions outside the mass spectrometer.
Dong, Jianan
core +2 more sources
Advanced ScienceElectrospray systems have been widely utilized in biomedical, pharmaceutical, and materials science applications due to their ability to enable precise liquid manipulation and efficient ionization.
Chaeyeong Kang +9 more
doaj +1 more source
Shaping electrospray plume with convergent sound beams
iScienceSummary: Electrospray ionization (ESI) is one of the mainstream ionization techniques for mass spectrometry (MS) nowadays. Here, we present a new variant of ESI-MS setup, in which an electrospray emitter points to the mass spectrometer’s orifice while ...
Yu-Hao Chen +2 more
doaj +1 more source