Results 51 to 60 of about 718,278 (381)

Single-Cell Analysis and Its Applications by Surface Desorption Ambient Mass Spectrometry

Zhipu Xuebao
As the fundamental units of the structure and function of living organisms, cells perform the core functions of life activities. With the deepening research in life sciences, the importance of studies on cellular heterogeneity has become increasingly ...
Dan LIN, Xi-yang GE, Xin-er XING, Yong HE, Jin OUYANG, Na NA   +5 more
doaj   +1 more source

Holography and Coherent Diffraction with Low-Energy Electrons: A Route towards Structural Biology at the Single Molecule Level [PDF]

, 2015
The current state of the art in structural biology is led by NMR, X-ray crystallography and TEM investigations. These powerful tools however all rely on averaging over a large ensemble of molecules.
Escher, Conrad, Fink, Hans-Werner, Latychevskaia, Tatiana, Longchamp, Jean-Nicolas   +3 more
core   +1 more source

Single Cell Metabolomics: A Future Tool to Unmask Cellular Heterogeneity and Virus-Host Interaction in Context of Emerging Viral Diseases

Frontiers in Microbiology, 2020
Viral emergence is an unpredictable but obvious event, particularly in the era of climate change and globalization. Efficient management of viral outbreaks depends on pre-existing knowledge and alertness.
Rajesh Kumar, Mayukh Ghosh, Sandeep Kumar, Minakshi Prasad   +3 more
doaj   +1 more source

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

FEBS Open Bio, EarlyView.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita, Toyonobu Usuki, Robert R. Kay, Tamao Saito   +3 more
wiley   +1 more source

Shaping electrospray plume with convergent sound beams

iScience
Summary: Electrospray ionization (ESI) is one of the mainstream ionization techniques for mass spectrometry (MS) nowadays. Here, we present a new variant of ESI-MS setup, in which an electrospray emitter points to the mass spectrometer’s orifice while ...
Yu-Hao Chen, Min-Min Hung, Pawel L. Urban   +2 more
doaj   +1 more source

Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]

, 2005
A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard.
Boyd, Denning, Dooley, Gage, Glasmacher, Hyland, Johnson, Keevil, Ozawa, Pennick, Potoski, Roffey, Stopher, Trifilio, Vogeser, Vogeser, Vogeser   +16 more
core   +1 more source

Single-Cell Analysis Using Drop-on-Demand Inkjet Printing and Probe Electrospray Ionization Mass Spectrometry.

Analytical Chemistry, 2016
This study describes a novel method for single-cell analysis and lipid profiling by combining drop-on-demand inkjet cell printing and probe electrospray ionization mass spectrometry (PESI-MS).
Fengming Chen, Luyao Lin, Jie Zhang, Ziyi He, K. Uchiyama, Jin‐Ming Lin   +5 more
semanticscholar   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Quantification of sirolimus by liquid chromatography-tandem mass spectrometry using on-line solid-phase extraction [PDF]

, 2002
Quantification of the new immunosuppressant sirolimus (syn. rapamycin; Rapamune((R))) in whole blood by chromatography is essential for its clinical use since no immunoassay is available although monitoring is mandatory.
Fleischer, Claudia, Groetzner, Jan, Meiser, Bruno, Seidel, Dietrich, Spöhrer, Ute, Vogeser, Michael   +5 more
core   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source