Results 121 to 130 of about 203,215 (351)

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

Advanced Science, EarlyView.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar, Hannah M. Hanson, Brianna L. Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J. Trimmer, Joseph M. Ciurca, Christopher J. Long, Christopher W. McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J. Hickman   +15 more
wiley   +1 more source

Deuterium exchange of α‐helices and β‐sheets as monitored by electrospray ionization mass spectrometry

, 1994
David S. Wagner, Laura G. Melton, Yibing Yan, Bruce W. Erickson, Robert J. Anderegg   +4 more
openalex   +1 more source

High-Performance Liquid Chromatography--Electrospray Ionization-Mass Spectrometry Study of Ginkgolic Acid in the leaves and Fruits of the Ginkgo Tree (Ginkgo biloba) [PDF]

, 2000
Xiaoxiao He, Matthew W. Bernart, G. S. Nolan, Lin Liu, Michael Lindenmaier   +4 more
openalex   +1 more source

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

Advanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra, Justin Garland, Rajani Rai, Donghua Zhao, Charuksha Walgama, Sadagopan Krishnan, Andrew T. Long, Tongzu Liu, Laura Adhikari, Doris M. Benbrook   +9 more
wiley   +1 more source

Tandem mass spectrometry of multiply charged proteins with electrospray ionization

, 1992
Joseph A. Loo, Richard Smith
openalex   +2 more sources

Studies on metal-ion complex formation of crown ether derivatives incorporating a photoionizable spirobenzopyran moiety by electrospray ionization mass spectrometry [PDF]

, 2000
Keiichi Kimura, Hidefumi Sakamoto, Shinpei Kado, Ryuichi Arakawa, Masaaki Yokoyama   +4 more
openalex   +1 more source

Heme/NADH Mimics Co‐Decorated Allosteric Capsules for Regulating Oxygen Activation and Upregulating Intracellular Methionine Depletion

Advanced Science, EarlyView.
Through modifying the switchable µ‐oxo bridged FeIII‐porphyrins moiety and NADH mimics into a metal‐organic capsule, multiple responsive manners for O2 activation, chemical oxygenation and metabolic transformation have been demonstrated for upregulating intracellular methionine depletion and accumulation of methionine sulfoxide to achieve effective ...
Chunming Ma, Yihao Zhang, Junkai Cai, Baotong Ding, Yang Jiao, Chunying Duan   +5 more
wiley   +1 more source

Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof

Angewandte Chemie, EarlyView.
PsiK from Psilocybe cubensis phosphorylates a diverse set of substituted phenols and benzenediols beyond its native substrate. High‐throughput screening of active site mutant libraries using DESI‐MS enabled protein engineering of PsiK, further expanding its substrate scope.
Ahram Kim, Nicolás M. Morato, Prabir Saha, Pascal N. Eyimegwu, Aqeel A. Niyaz, Rui Huang, R. Graham Cooks, Ryan M. Phelan, Jared C. Lewis   +8 more
wiley   +2 more sources

Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells

Journal of Lipid Research, 2006
Maturation of fetal alveolar type II epithelial cells in utero is characterized by specific changes to lung surfactant phospholipids. Here, we quantified the effects of hormonal differentiation in vitro on the molecular specificity of cellular and ...
Anthony D. Postle, Linda W. Gonzales, Wolfgang Bernhard, Graeme T. Clark, Marye H. Godinez, Rodolfo I. Godinez, Philip L. Ballard   +6 more
doaj  

Solvent Effects on the Conformation of the Transmembrane Peptide Gramicidin A: Insights from Electrospray Ionization Mass Spectrometry [PDF]

, 2000
Mario Bouchard, Dennis R. Benjamin, Paula Tito, Carol V. Robinson, Christopher M. Dobson   +4 more
openalex   +1 more source