Results 101 to 110 of about 3,602,918 (298)

Investigating the interactions and conformations of metalloproteins by means of mass spectrometry [PDF]

The use of mass spectrometry for the study of proteins and their non-covalent interactions has expanded rapidly since the introduction of ionisation techniques capable of transferring intact complexes into the gas phase.
Kondrat, Frances D. L.
core  

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Characterization of Proanthocyanidins from Parkia biglobosa (Jacq.) G. Don. (Fabaceae) by Flow Injection Analysis — Electrospray Ionization Ion Trap Tandem Mass Spectrometry and Liquid Chromatography/Electrospray Ionization Mass Spectrometry

Molecules, 2013
The present study investigates the chemical composition of the African plant Parkia biglobosa (Fabaceae) roots and barks by Liquid Chromatography - Electrospray Ionization and Direct Injection Tandem Mass Spectrometry analysis.
Wagner Vilegas, Lourdes Campaner dos Santos, Augustin Ephrem Nkengfack, Clenilson Martins Rodrigues, Viviane Candida da Silva, Viviane Raïssa Sipowo Tala   +5 more
doaj   +1 more source

Unlocking Long‐Lived Charge‐Separated State in Pentamethine Cyanine Based on Anionic Hofmeister Effect for Photodynamic Immunotherapy

Advanced Science, EarlyView.
Based on the anionic Hofmeister effect, a universal strategy of incorporation of stereo‐π anion BPh4− into a series of Cy5 skeletons to unlock long‐lived charge‐separated states was reported, wherein the weak electronic coupling and low charge recombination driving force hinder the charge recombination process, elevating the oxygen‐independent ROS ...
Xuan Zhao, Lei Jiang, Yingyong Ni, Ting Wang, Junjun Wang, Shengyu Shi, Jianhua Yu, Zhou Lu, Xiaojiao Zhu, Hongping Zhou   +9 more
wiley   +1 more source

Liquid chromatography-tandem mass spectrometry - Application in the clinical laboratory [PDF]

, 2003
This review provides a concise survey of liquid chromatography tandem mass spectrometry (LCTMS) as an emerging technology in clinical chemistry. The combination of two mass spectrometers with an interposed collision cell characterizes LCTMS as an ...
Michael Vogeser, Vogeser, Michael
core   +2 more sources

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Espectrometria de massas com ionização por "electrospray": processos químicos envolvidos na formação de íons de substâncias orgânicas de baixo peso molecular

Química Nova, 2006
An overview of the current literature on the chemical processes involved in the ion formation from low molecular weight organic compounds by electrospray ionization mass spectrometry is given.
Crotti Antônio Eduardo Miller, Vessecchi Ricardo, Lopes João Luis Callegari, Lopes Norberto Peporine   +3 more
doaj  

Identification of phosphatidylserylglutamate: a novel minor lipid in Escherichia coli

Journal of Lipid Research, 2009
Advances in mass spectrometry have facilitated the identification of novel lipid structures. In this work, we fractionated the lipids of Escherichia coli B and analyzed the fractions using negative-ion electrospray ionization mass spectrometry to reveal ...
Teresa A. Garrett, Christian R.H. Raetz, Travis Richardson, Reza Kordestani, Jennifer D. Son, Rebecca L. Rose   +5 more
doaj   +1 more source

Reversible addition-fragmentation chain-transfer polymerization: Unambiguous end-group assignment via electrospray ionization mass spectrometry

, 2002
Electrospray ionization mass spectrometry was performed to identify the structure of polymeric methyl acrylates generated via the cumyl dithiobenzoate (CDB), cumyl p-fluorodithiobenzoate (CPFDB), and 1-phenylethyl dithiobenzoate (PEDB) mediated ...
Davis, T. P., Barner, Leonie, Barner, L, Vana, Philipp, Vana, P, Davis, TP, Albertin, L, Barner-Kowollik, C., Davis, Thomas P., Albertin, L., Vana, P., Barner-Kowollik, C, Barner, L., Barner-Kowollik, Christopher, Albertin, Luca   +14 more
core   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source