Results 91 to 100 of about 3,602,918 (298)

Imaging mass spectrometry approaches for the detection and localisation of drug compounds and small molecules in tissue [PDF]

A crucial and challenging aspect of the drug development process is the requirement to measure the distribution of a pharmaceutical compound and its metabolites in tissue.
Blatherwick, Eleanor Q.
core  

Magnetic Water Cleaning of Estrogens via Tight yet Dynamic Binding to Nanoparticles

Advanced Science, EarlyView.
Micropollution is one of the big challenges humanity faces with estrogen hormones being emerging pollutants of concern. Here, a supramolecular design strategy is presented that generates a simple nano‐adsorbent material to magnetically remove low‐concentrated estrogens from water.
Lukas Müller, Philip Maier, Dustin Vivod, Wenke Müller, Nikolaj Lopatik, Theresa Maria Schichtl, Julia Fröhlich, Irene Kraus, Marten Huck, Wieland Corts, Clodomiro Cafolla, Lukas Ruhm, Henrik Gaß, Johannes Voß, Jiwon Byun, Linda Rockmann, Guido Grundmeier, Kislon Voïtchovsky, Hans‐Georg Steinrück, Erdmann Spiecker, Sevim Dalabasmaz, Monika Pischetsrieder, Eike Brunner, Ralf Schweins, Dirk Zahn, Marcus Halik   +25 more
wiley   +1 more source

Glycomics expression analysis of sulfated glycosaminoglycans of human colorectal cancer tissues and non-neoplastic mucosa by electrospray ionization mass spectrometry

Einstein (São Paulo)
Objective To determine the presence of glycosaminoglycans in the extracellular matrix of connective tissue from neoplastic and non-neoplastic colorectal tissues, since it has a central role in tumor development and progression.
Ana Paula Cleto Marolla, Jaques Waisberg, Gabriela Tognini Saba, Daniel Reis Waisberg, Fernando Beani Margeotto, Maria Aparecida da Silva Pinhal   +5 more
doaj   +1 more source

Differentiation between 3,4- and 4,15-Epoxyeudesmanolides by Electrospray Ionization Tandem Mass Spectrometry

Journal of Analytical Methods in Chemistry, 2017
We investigated the fragmentation of the eudesmanolide-type sesquiterpene lactones 1α-(4-hydroxymethacryloyloxy)-3α,4α-epoxy-8α-hydroxyeudesm-11(13)-6α,12-olide (1) and 1α-(2,3-epoxyangeloyloxy)-4α,15-epoxy-8α-hydroxyeudesm-11(13)-6α,12-olide (2) by ...
Herbert Júnior Dias, Ricardo Stefani, José Carlos Tomaz, Ricardo Vessecchi, Antônio Eduardo Miller Crotti   +4 more
doaj   +1 more source

Determination of serum cortisol by isotope-dilution liquid-chromatography electrospray ionization tandem mass spectrometry with on-line extraction [PDF]

, 2001
A liquid chromatographic-mass spectrometric method for the determination of cortisol in serum using atmospheric pressure electrospray ionization and tandem mass spectrometry is described.
Briegel, Josef, Jacob, Karl, Vogeser, Michael   +2 more
core   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Correction: Taliaferro, L. et al. Evaluation of the Broad-Range PCR-Electrospray Ionization Mass Spectrometry (PCR/ESI-MS) System and Virus Microarrays for Virus Detection. Viruses 2014, 6, 1876-1896

Viruses, 2014
We have noted some inaccuracies in Table 1 and Table 2 of our article “Evaluation of the Broad-Range PCR-Electrospray Ionization Mass Spectrometry (PCR/ESI-MS) System and Virus Microarrays for Virus Detection” (Viruses 2014, 6, 1876–1896) [1].[...]
Lanyn P. Taliaferro, Teresa A. Galvin, Hailun Ma, Syed Shaheduzzaman, Dhanya K. Williams, Dustin R. Glasner, Arifa S. Khan   +6 more
doaj   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Shaping electrospray plume with convergent sound beams

iScience
Summary: Electrospray ionization (ESI) is one of the mainstream ionization techniques for mass spectrometry (MS) nowadays. Here, we present a new variant of ESI-MS setup, in which an electrospray emitter points to the mass spectrometer’s orifice while ...
Yu-Hao Chen, Min-Min Hung, Pawel L. Urban   +2 more
doaj   +1 more source

Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells

Journal of Lipid Research, 2006
Maturation of fetal alveolar type II epithelial cells in utero is characterized by specific changes to lung surfactant phospholipids. Here, we quantified the effects of hormonal differentiation in vitro on the molecular specificity of cellular and ...
Anthony D. Postle, Linda W. Gonzales, Wolfgang Bernhard, Graeme T. Clark, Marye H. Godinez, Rodolfo I. Godinez, Philip L. Ballard   +6 more
doaj   +1 more source