Results 91 to 100 of about 195,229 (259)

Bidirectional Photoswitching of a Tailored Azobenzene with Red and Far‐Red Light Involving Triplet Sensitization in an Aqueous System

Advanced Science, EarlyView.
The action spectrum of a tailored azobenzene is shifted toward bio‐optical window through the chemical modification of its singlet and triplet energy levels. Consequently, the bidirectional photo‐switching of azobenzene in physiological conditions is achieved when excited by red and far‐red light, which offers greater tissue penetration.
Mila Miroshnichenko, Helen Hölzel, Edvinas Orentas, Karolis Kazlauskas, Pedro Ferreira, Fabienne Dumoulin, Carles Alcaide, Miquel Solà, Roger Bresolí‐Obach, Santi Nonell, Pankaj Bharmoria, Kasper Moth‐Poulsen   +11 more
wiley   +1 more source

Compositional Analysis of Adsorbed Organic Aerosol on a Microresonator Mass Sensor [PDF]

, 2018
Campbell, Steven J., Giorio, Chiara, Jones, Roderic L., Kalberer, Markus, Seshia, Ashwin A., Zielinski, Arthur T.   +5 more
core   +1 more source

Advances in Microfluidics and Lab-on-a-Chip Technologies

, 2017
Advances in molecular biology are enabling rapid and efficient analyses for effective intervention in domains such as biology research, infectious disease management, food safety, and biodefense.
Abate, Adley, Aebersold, Ahlford, Almassian, Almoguera, Asiello, Athamanolap, Baker, Becker, Blazej, Brehm-Stecher, Burger, Business-Wire, Byrnes, Cai, Cao, Chang, Chao, Chatterjee, Chin, Chin, Coupland, Craw, Crews, Crews, Czilwik, Derveaux, DeVoe, Dharmasiri, Dodsworth, Domon, Duffy, Erlich, Farrar, Fredrickson, Fu, Gagnon, Gao, Gonzalez de Castro, Grover, Hadd, Han, Hanyoup, Hardouin, Hauck, Hayden, He, He, He, Hindson, Ho, Hsieh, Huang, Hughes, Jacobs, Jansson, Jarvius, Jayamohan, Jayamohan, Jenkins, Jha, Ji, Jin, Jin, Kalra, Karimi, Karns, Khandurina, Kim, Kim, Kim, Kim, Kim, Klein, Klostranec, Konry, Kuroda, Kwasny, Kwasny, Kühnemund, Küster, Lagally, Lapierre, Lazar, Lazar, Lee, Lee, Lee, Li, Liu, Lochovsky, Macosko, Mahmoudian, Mani, Manz, Mao, Mariella, Melin, Mery, Metzker, Mezger, Mitchell, Mitchell, Neuzil, Ng, Northen, Oblath, Oxford Nanopore, Paegel, Paegel, Paliwal, Park, Pekin, Pennisi, Perez-Toralla, Pješčić, Pješčić, Pješčić, Prakash, Priye, Priye, Quick, Ro, Romanov, Safavieh, Sainiemi, Samuel, Sanvicens, Sato, Sayad, Schoenitz, Schuler, Shamsi, Shih, Song, Srbek, Stumpf, Sun, Sundberg, Tanaka, Teh, Tehranirokh, Thompson, Thuy, Tian, Tröger, Unger, Vergauwe, Volpatti, Weisenberger, Wheeler, Whitesides, Woolley, Xie, Xu, Xue, Yetisen, Yin, Zhang, Zhang, Zhu   +161 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Amplification of Endoplasmic Reticulum Stress via Inhibiting Lipid Droplet Formation to Enhance Chemodynamic Immunotherapy

Advanced Science, EarlyView.
An endoplasmic reticulum (ER)‐targeted chemodynamic nanoagent (TCBQ/iLD‐ER NPs) comprising •OH‐generating tetrachloro‐1,4‐benzoquinone (TCBQ) and lipid droplets (LDs) formation inhibitor (iLD) is developed for chemodynamic immunotherapy of tumors. After ingestion by cancer cells, TCBQ/iLD‐ER NPs preferentially accumulate in the ER and react with ER ...
Huilan Cai, Shaoru Zhuang, Yang Zhu, Rujiang Ao, Meili Yu, Tingting Cui, Jun Wang, Xuegang Niu, Hongwei Huang, Shanshan Peng, Yu He, Lisen Lin, Huanghao Yang   +12 more
wiley   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source

Studies of the complexation behavior of tetramorpholinylo-PNP-lariat ether with Ag(I), Ca(II), Cd(II), Cu(II) and Pb(II) using Electrospray Ionization Mass Spectrometry [PDF]

, 2014
In this publication the cationic metal complexes of tetramorpholinylo-PNP-lariat ether have been studied using electrospray ionization mass spectrometry (ESI-MS).
Andrijewski, Grzegorz, Gutowska, Natalia, Pasternak, Beata, Seliger, Piotr   +3 more
core