Results 31 to 40 of about 11,515 (253)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Naturalness sum rules and their collider tests

Journal of High Energy Physics, 2019
We present the most general sum rules reflecting the cancellation of ultraviolet divergences in the Higgs potential, which provide necessary conditions for any weakly-coupled extension of the Standard Model to be natural. There is a separate sum rule for
Csaba Csáki, Felipe Ferreira De Freitas, Li Huang, Teng Ma, Maxim Perelstein, Jing Shu   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Strip-based Scintillation Detector for Dual-readout High-granularity Calorimetry [PDF]

EPJ Web of Conferences
New calorimeter technology is being developed for future collider experiments. We are developing a calorimeter that integrates two technologies, a high-granularity calorimeter and a dual-readout calorimeter, and has high time resolution at a picosecond ...
Ogawa Hiroyasu, Freeman James, Gatto Corrado, Jeans Daniel, Kamiyama Taiki, Li Weiyuan, Matsuoka Kodai, Ootani Wataru, Suehara Taikan, Takeshita Tohru   +9 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Spontaneous CP breaking in a QCD-like theory

Journal of High Energy Physics
We examine the phase structure of a QCD-like theory at θ ¯ $$ \overline{\theta} $$ = π obtained from supersymmetric SU(N) QCD perturbed by a small amount of supersymmetry breaking via anomaly mediation (AMSB QCD). The spectrum of this theory matches that
Csaba Csáki, Maximilian Ruhdorfer, Taewook Youn   +2 more
doaj   +1 more source

Texture zero neutrino models and their connection with resonant leptogenesis

Nuclear Physics B, 2018
Within the low scale resonant leptogenesis scenario, the cosmological CP asymmetry may arise by radiative corrections through the charged lepton Yukawa couplings.
Avtandil Achelashvili, Zurab Tavartkiladze   +1 more
doaj   +1 more source

Trace Elements Concentrations in Urban Air in Helsinki, Finland during a 44-Year Period

Atmosphere, 2023
The atmospheric concentrations of seventeen elements were measured in air filters at the Finnish Meteorological Institute station in Helsinki, Finland, during a period of 44 years (1962–2005).
Eleftheria Ioannidou, Stefanos Papagiannis, Manousos Ioannis Manousakas, Chrysoula Betsou, Konstantinos Eleftheriadis, Jussi Paatero, Lambrini Papadopoulou, Alexandra Ioannidou   +7 more
doaj   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source