Results 81 to 90 of about 339,404 (276)

Reviewing the understanding of the effects of spacing on children’s eye movements for on-screen reading

, 2008
This paper endeavors to consolidate current knowledge and empirical research concerning the use of typography for children’s on-screen reading. This paper is not intended as a full literature review but attempts to raise awareness of the areas required ...
Vanderschantz, Nicholas
core  

Discourse organisation through Theme position [PDF]

, 2016
This paper focuses on the role of elements placed in the initial position i.e. elements fulfilling the role of Theme in discourse organisation. The large-scale corpus study proposes a new methodology based on quantitative analysis of the discourse roles ...
Ho-Dac, Lydia-Mai
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Development of a high resolution magnetic field position sensor system based on a through silicon via first integration concept

, 2022
S.916-925This paper presents the conception, the fabrication, first characterization results as well as application scenarios for a new position sensor system architecture based on tunnelmagnetoresistive (TMR) technology.
Frank, P., Knoll, H., Lenkl, A., Oppermann, H., Braun, F.-J., Paul, J., Theis, M., Saumer, M., Klose, F., Zoschke, Kai   +9 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Heterogeneous-IRS-Assisted Millimeter-Wave Systems: Element Position and Phase Shift Optimization

Sensors
Intelligent reflecting surfaces (IRSs) have attracted extensive attention in the design of future communication networks. However, their large number of reflecting elements still results in non-negligible power consumption and hardware costs.
Weibiao Zhao, Qiucen Wu, Hao Wei, Dongliang Su, Yu Zhu   +4 more
doaj   +1 more source

Three-Dimensional Position Measurement of a Microrobot [PDF]

, 2003
Many microrobots with various types of sensors and actuators have been developed. We propose three-dimensional position measurement of a microrobot using position sensitive detectors (PSDs), since its dimension is suitable for the microrobot.
川根, 祐輔, 鳥井, 昭宏, 植田, 明照, 道木, 加絵   +3 more
core  

Conceptualizing "precarious prosperity": Empirical and theoretical elements for debate

, 2010
International audienceEmpirical studies have recently pointed towards a structural position largely overlooked in social inequality research so far: the dynamic location in vicinity of the poor and yet not part of the established, more prosperous ...
Wiebke Keim, Michèle Amacker, Amacker, Michèle, Monica Budowski, Robin Tillmann, Keim, Wiebke, Tillmann, Robin, Budowski, Monica   +7 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source