Results 61 to 70 of about 339,404 (276)

Challenge-Based Learning in Higher Education : A Malmö University Position Paper

, 2022
Higher education institutions (HEIs) have a pivotal role in fulfilling the social dimension of sustainability and contributing to a complex changing society.
Melin, Margareta,, Christensen, Jonas,, Staaf, Patricia,, Christensen, Jonas, Melin, Margareta, Christersson, Cecilia E.,, Widén, Pär, Widén, Pär,, Ekelund, Nils,, Ekelund, Nils, Lundegren, Nina, Christersson, Cecilia E., Staaf, Patricia, Lundegren, Nina,   +13 more
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Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Use of independent volume parameters in the development of new large displacement ANCF triangular plate/shell elements

, 2018
In this paper, a new unified kinematic description, obtained from Bezier geometry using linear mapping and position vector gradients associated with three independent parameters, is used to develop large displacement plate/shell finite elements (FE ...
Carmine M. Pappalardo, Ahmed A. Shabana, Zhigang Zhang (20860), Ahmed A. Shabana (8001062), Zhigang Zhang, Shabana, A. A., Zhang, Z., Pappalardo, C. M., Carmine M. Pappalardo (8001086)   +8 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

ELEMENTS: A high-order finite element library in C++

SoftwareX, 2019
We discuss the creation and implementation of a generalized library, named ELEMENTS, of mathematical functions for supporting a very broad range of element types including: linear, quadratic, and cubic serendipity elements in 2D and 3D; high-order ...
Jacob L. Moore, Nathaniel R. Morgan, Mark F. Horstemeyer   +2 more
doaj   +1 more source

The Analysis and the Design of the Reinforced Concrete Elements and the Algorithm in the Calculation of these Elements under the Shear Forces [PDF]

, 2013
During the process of the design for the reinforced concrete elements besides the calculation of the bending moment, another important calculation is the one made for these elements when they are under the shear forces.
Brunela Karamani; Polytechnic University of Tirana, Julian Kasharaj; Polytechnic University of Tirana, Igli Kondi; Polytechnic University of Tirana   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efficient computation of motion error of parallel robots with joint clearances based on joint force model

Nihon Kikai Gakkai ronbunshu, 2018
This paper proposes a method to compute positioning error of a parallel mechanism having passive spherical joints with clearances in motion without numerical integration nor iterative calculation.
Masumi OHNO, Yukio TAKEDA
doaj   +1 more source

Cyclic phonology–syntax-interaction : movement to first position in German

, 2004
This paper investigates the nature of the attraction of XPs to clauseinitial position in German (and other languages). It argues that there are two different types of preposing.
Fanselow, Gisbert (Prof. Dr.)
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