Restraint-induced hypoactivity in an elevated plus-maze [PDF]
Brazilian Journal of Medical and Biological Research, 2000 Rodents submitted to restraint stress show decreased activity in an elevated plus-maze (EPM) 24 h later. The objective of the present study was to determine if a certain amount of time is needed after stress for the development of these changes.
C.M. Padovan, F.S. Guimarães
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Comparative analysis between Open Field and Elevated Plus Maze tests as a method for evaluating anxiety-like behavior in mice. [PDF]
Heliyon, 2023 Anxiety is being increasingly diagnosed in the elderly population. In this sense, epidemiologic data have linked late-life anxiety disorders to increased cognitive decline, morbidity, and even mortality.
Figueiredo Cerqueira MM +6 more
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Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test. [PDF]
Mol Brain, 2021 The elevated plus maze test is a widely used test for assessing anxiety-like behavior and screening novel therapeutic agents in rodents. Previous studies have shown that a variety of internal factors and procedural variables can influence elevated plus ...
Shoji H, Miyakawa T.
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Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze [PDF]
Advances in Pharmacological Sciences, 2012 The present study was designed to evaluate the effect of palmatine on memory of Swiss young male albino mice. Palmatine (0.1, 0.5, 1 mg/kg, i.p.) and physostigmine (0.1 mg/kg, i.p.) per se were administered for 10 successive days to separate groups of ...
Dinesh Dhingra, Varun Kumar
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Computer-assisted scoring of the elevated plus maze
BioTechniques, 2006 Paresh D. Patel +2 more
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Elevated Plus Maze for Mice [PDF]
Journal of Visualized Experiments, 2008 Although the mouse genome is now completely sequenced, the functions of most of the genes expressed in the brain are not known. The influence of a given gene on a specific behavior can be determined by behavioral analysis of mutant mice. If a target gene is expressed in the brain, behavioral phenotype of the mutant mice could elucidate the genetic ...
Komada, Munekazu +2 more
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Deuterium depletion induces anxiolytic-like effects in rats [PDF]
Archives of Biological Sciences, 2014 Deuterium-depleted water (DDW) has a concentration of deuterium 6-7 times lower than naturally occurring water (20-25 ppm vs. 150 ppm). When administered for a longer period, it can reduce the concentration of deuterium throughout the body ...
Mladin Cristian +4 more
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Neuropharmacological evaluation and HPTLC fingerprint profile of phytocompound-enriched chloroform fraction of methanolic extract of Lagenaria siceraria (Molina) Standley fruits – a potent Asian ethno-medicinal vegetable plant [PDF]
Folia Medica, 2022 Introduction: Lagenaria siceraria (Molina) Standley (Cucurbitaceae) is a traditional vegetable plant, popularly known as bottle gourd (English) and lauki (Hindi). It is a climbing herb characterized with a number of therapeutic properties.
Sachin Parmar +2 more
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Anxiolytic activity of Berberis aristata root extract in mice
BLDE University Journal of Health Sciences, 2020 BACKGROUND: Anxiety is a common emotional response in humans and it is one of most common psychiatric illnesses. Interest in herbal drugs is growing nowadays for the optimum treatment of anxiety. The aim of the present study was to explore the anxiolytic
Divya Goel
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Elevated plus maze protocol v1
, 2022 This protocol describes steps for assessing anxiety-like behavior in rodents using an elevated plus maze test. The elevated plus maze (EPM) is one of the widely used behavioral assays to measure anxiety-like behaviors in rodents. In the EPM test, rats or mice are placed at the intersection of a plus-shaped maze with two open arms and two closed arms.
Archana Venkataraman, Holly Ingraham
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