Results 121 to 130 of about 96,671 (319)

Stressor- and Corticotropin releasing Factor-induced Reinstatement and Active Stress-related Behavioral Responses are Augmented Following Long-access Cocaine Self-administration by Rats [PDF]

, 2008
Rationale Stressful events during periods of drug abstinence likely contribute to relapse in cocaine-dependent individuals. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing
AM Basso, B Costall, B Costall, B Lee, B Wang, B Wang, BA Sorg, BA Sorg, CJ Sanchez, David A. Baker, David M. Francis, DJ Lodge, EB Souza De, EP Zorrilla, Eric S. Katz, G Paxinos, HC Fox, J Liu, John R. Mantsch, Joseph P. Serge, JR Mantsch, JR Mantsch, K McFarland, L Lu, L Lu, LJMJ Vanderschuren, LM Najavits, LW Swanson, MA Sutton, MA Ungless, Michael A. Hoks, N Capriles, NE Goeders, NE Goeders, NH Mutschler, PW Kalivas, PW Kalivas, R Sinha, R Sinha, RA Fuchs, RE Sorge, RM Richter, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Pellow, S Pollandt, SH Ahmed, SH Ahmed, SH Ahmed, SH Ahmed, TE Kippin, TM Korotkova, V Deroche-Gamonet, Y Shaham, Y Zhou, Z Sarnyai, Z Sarnyai   +62 more
core   +2 more sources

Alprazolam modifies animal behaviour on elevated plus-maze.

Indian journal of experimental biology, 1994
Exposure to elevated plus-maze is known to evoke approach-avoidance conflict behaviour and anxiety related movements in mice. Alprazolam (0.1 to 1 mg/kg, ip) produced dose dependant increase in antianxiety response, 100% first preference to open arm, open arm entries and exploratory behaviour.
S K, Kulkarni, K, Sharma
openaire   +1 more source

Microglial Membranes Wrapped Ultrasmall Medium‐Entropy Ru Single‐Atom Nanozyme: Enhanced Catalysis for Accelerating Inflammation/Redox Microenvironment Regulation in Intracerebral Hemorrhage

Advanced Science, EarlyView.
PtRhIr/Ru SAN@M nanozymes cross the blood–brain barrier and selectively accumulate in hemorrhagic brain regions. By mimicking multiple enzyme activities, they attenuate oxidative stress, modulate microglial polarization toward an anti‐inflammatory phenotype, inhibit ferroptosis, and promote neuronal repair.
Jiebo Li, Penghui Wei, Yuanbo Pan, Hongjia Zheng, Jiajun Hu, Qianxi Chen, Zhongyuan Shen, Yongrui Hu, Jiajun Wu, Fuxin Lin, Fuxiang Chen, Chenyu Ding, Wenhua Fang, Yuanxiang Lin, Dezhi Kang, Yuxiang Gu, Yang Zhu, Dengliang Wang   +17 more
wiley   +1 more source

Early handling and repeated cross-fostering have opposite effect on mouse emotionality [PDF]

, 2015
Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders.
Battaglia, M, CENTOFANTE, ELEONORA, D'Amato, F.r., Felsani, A, Lampis, V, LUCHETTI, ALESSANDRA, ODDI, DIEGO   +6 more
core   +2 more sources

THE EFFECTS OF FLUOXETINE IN THE ELEVATED PLUS MAZE TEST

Psychiatry and Clinical Psychopharmacology, 2021
W e have studied the effects of fluoxetine, a selective serotonin reuptake inhibitor, on anxiety by using elevated plus m aze tc in m ice. A cute intraperitoneal adm inistration of fluoxetine (20 m g/kg) decreased the time spent in the open arm s ...
Mehmet KURT, Ali Cezmi ARIK, Gülay ÖZDEMİR, Süleyman ÇELİK   +3 more
doaj  

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Elevated plus maze test for mice v1

The elevated plus maze is a classical test to screen anxiety-like behaviors in laboratory animals. This protocol is optimized to mice. The protocol also describes the use of Biobserve Viewer, which is is a software to track online the movement of animals.
Csilla Novák, Andrés Mauricio Jaramillo Flautero, Matthias Prigge   +2 more
openaire   +1 more source

Anxiolytic effect of methylene blue microinjected into the dorsal periaqueductal gray matter

Brazilian Journal of Medical and Biological Research, 1999
The dorsal periaqueductal gray (DPAG) has been implicated in the behavioral and autonomic expression of defensive reactions. Several results suggest that, along with GABA, glutamate and serotonin, nitric oxide (NO) may play a role in defense reactions ...
R.W. de-Oliveira, F.S. Guimarães
doaj   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source