Elevated plus maze protocol v1
, 2022 This protocol describes steps for assessing anxiety-like behavior in rodents using an elevated plus maze test. The elevated plus maze (EPM) is one of the widely used behavioral assays to measure anxiety-like behaviors in rodents. In the EPM test, rats or mice are placed at the intersection of a plus-shaped maze with two open arms and two closed arms.
Archana Venkataraman, Holly Ingraham
openaire +1 more source
The submerged plus maze as an assay for studying anxiety-like behaviour in fish
MethodsX, 2019 The elevated plus maze is a commonly used and well-validated test of anxiety-related behaviour in rodents. The use of fish in behavioural neuroscience paradigms is increasing, necessitating an equivalent test for studying anxiety-like behaviour in fish ...
Brittany V. Hope +2 more
doaj +1 more source
α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter [PDF]
, 2016 We studied the impact of α-synuclein overexpression in brainstem serotonin neurons using a novel vector construct where the expression of human wildtype α-synuclein is driven by the tryptophan hydroxylase promoter, allowing expression of α-synuclein at ...
Bjorklund, Anders +5 more
core +1 more source
Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]
, 2006 It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Broide R.S. +11 more
core +2 more sources
Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze
Prague Medical Report, 2012 Methamphetamines (MA) are psychostimulant drugs that are known to change individuals’ behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans.
Marie Pometlová +2 more
doaj +1 more source
A phenotypic and molecular characterization of the fmr1-tm1Cgr Fragile X mouse [PDF]
, 2004 Fragile X Syndrome is the most common form of\ud inherited mental retardation. It is also known for having\ud a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always\ud caused by inactivation of the
Bauchwitz, Dr. Robert P.
core +1 more source
Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice [PDF]
, 2016 Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L.
Chen, Ling +11 more
core +2 more sources
Influências do ciclo estral sobre o desempenho de ratos no labirinto em cruz elevado
Interação em Psicologia, 2002 The Elevated plus maze is one of the most popular models to study animal anxiety. Anxiety can be influenced by physiological factors, such as the hormonal state.
Amauri Gouveia Júnior, Silvio Morato
doaj +1 more source
Minimal long-term neurobehavioral impairments after endovascular perforation subarachnoid hemorrhage in mice [PDF]
, 2017 Cognitive deficits are among the most severe and pervasive consequences of aneurysmal subarachnoid hemorrhage (SAH). A critical step in developing therapies targeting such outcomes is the characterization of experimentally-tractable pre-clinical models ...
Brody, David L +5 more
core +2 more sources
Dose-related effects of propericiazine in rats
Brazilian Journal of Medical and Biological Research, 2003 We evaluated the effects of the neuroleptic agent propericiazine on animal models of anxiety and memory. Adult male Wistar rats (250 to 350 g) received intraperitoneal injections of propericiazine (0.05, 0.075 and 0.1 mg/kg), diazepam (1 mg/kg), saline ...
E.M. Cechin +5 more
doaj +1 more source