Results 41 to 50 of about 64,796 (205)

Anxiolytic and antidepressive effects of magnesium in rats and their effect on general behavioural parameters [PDF]

Veterinarski Glasnik, 2011
Magnesium (Mg) is an essential element that catalyses more than 300 enzyme systems. Its effects on the central nervous system are exhibited through the blocking of activity of N-methyl D-aspartat (NMDA) receptors and potentiating of GABA-ergic ...
Samardžić Janko, Savić Kristina, Baltezarević Dragana, Matunović Radomir, Obradović Miljana, Jančić Jasna, Obradović Dragan I.   +6 more
doaj   +1 more source

Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. [PDF]

, 2018
Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts ...
Campbell-Beachler, Mary, Chou, Austin, Feng, Xi, Grue, Katherine, Jones, Tamako, Krukowski, Karen, Nelson, Gregory, Paladini, Maria Serena, Riparip, Lara-Kirstie, Rosi, Susanna, Sacramento, Kristen   +10 more
core   +2 more sources

Evaluation of the Effect of Acute Sibutramine in Female Rats in the Elevated T-Maze and Elevated Plus-Maze Tests [PDF]

Basic & Clinical Pharmacology & Toxicology, 2013
Sibutramine is a serotonin and norepinephrine reuptake inhibitor indicated for the treatment of obesity. A pre-clinical study showed that acute administration of sibutramine promoted anxiolytic- and panicolytic-like effects in male rats. However, in clinical reports, sibutramine favoured the onset of panic attacks in women. In this study, the effect of
Raliny O, Santos, Gabriela L M, de Assunção, Diogo M B, de Medeiros, Icaro A, de Sousa Pinto, Keizianny S, de Barros, Bruno L, Soares, Eunice, André, Elaine C, Gavioli, Vanessa, de Paula Soares-Rachetti   +8 more
openaire   +2 more sources

Removal of GABAA receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations [PDF]

, 2011
We investigated the behavioral significance of fast synaptic inhibition by αβγ2-type GABA(A) receptors on parvalbumin (Pv) cells. The GABA(A) receptor γ2 subunit gene was selectively inactivated in Pv-positive neurons by Cre/loxP recombination.
Leppa, E., Linden, A., Vekovischeva, O., Swinny, Jerome, Rantanen, V., Toppila, E., Hoger, H., Sieghart, W., Wulff, P., Wisden, W., Korpi, E.   +10 more
core   +1 more source

Anxiolytic Effect of L-carnitine in Adult Male Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2014
Background and Objectives: The beneficial effect of L-carnitine for treatment of neurological diseases has been investigated in various studies. The aim of the present study was to investigate the effect of L-carnitine supplement on anxiety behavior in ...
Zahra Sasaninejad, Maryam Eidi, Reza Ghahramani, Zeinab Ahmarinejad, Ali Rezaei Galeshpol, Fatemeh Rasoulian, Ali Ilchizadeh Kavgani, Marzieh Hajizadeh   +7 more
doaj  

Evaluation of Anxiolytic-like Effects of Some Short-Acting Benzodiazepine Hypnotics in Mice

Journal of Pharmacological Sciences, 2008
Anxiolytic-like effects of some short-acting benzodiazepine hypnotics were examined with experimental paradigms of anxiety using an elevated plus-maze in male ICR mice. Diazepam was used as a positive control.
Tomomi Nishino, Tomoko Takeuchi, Kenshi Takechi, Chiaki Kamei   +3 more
doaj   +1 more source

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors [PDF]

, 2015
Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence.
A Busquets-Garcia, A Castañé, A Kern, A Manglik, A Pazos, A Pertovaara, A Zimmer, AC Magalhaes, AJ Venkatakrishnan, AL Bodor, Antoni Pastor, AR Best, Arnau Cordomí, BB Gorzalka, C Bombardi, C Castellano, C Ferrada, C Sanchis-Segura, Carmen Lluís, CP Vandermaelen, E Aso, E Fiorica-Howells, E Moreno, E Moreno, E Moreno, E Palazzo, E Puighermanal, E Puighermanal, E Valjent, Enric I. Canela, Eric J. Nestler, Estefanía Moreno, ET Weber, F Berrendero, F Rodríguez de Fonseca, F Simonin, F Steindel, FA Moreira, G Di Chiara, G Mengod, G Paxinos, G Porras, G Soria, Gemma Navarro, GM Thomas, HY Meltzer, J De Almeida, J González-Maeso, J González-Maeso, JC Parrish, JF Cheer, JF López-Giménez, JF López-Giménez, JJ Rodriguez, JM Franklin, JM Walker, JR Clapper, K Baba, K Mackie, K Monory, K Tsou, K Tsou, KA Gleason, L a. H Miner, L Callén, L Lanfumey, Laurence Lanfumey, Leonardo Pardo, Lesley A. Howell, LJ Sim-Selley, LP Martin, LTO Lee, M Bouvier, M Fribourg, M Lüttgen, M Schneider, M-M Mocanu, MJ Orejarena, N Kabli, NA Darmani, NB Eddy, NV Weisstaub, O Söderberg, P Pacher, P Rivera, Paola Gasperini, Patricia Robledo, Peter J. McCormick, R Franco, R Maldonado, R Mechoulam, R Mongeau, R Nygaard, R Schroder, Rafael de La Torre, Rafael Maldonado, RL Jakab, S Ferre, S Ferré, S Ferré, S González, S Haj-Dahmane, S Mato, S Pellow, SGF Rasmussen, SGF Rasmussen, SM Eggan, T Issad, T-W Chen, V Mendizábal, X Guitart, Xavier Viñals, Y-C Chiang   +112 more
core   +6 more sources

Evaluation the effect of neuropeptide of Bombesin on modulation of anxiety reaction in mice

مجله دانشگاه علوم پزشکی گرگان, 2007
Background & Objective: Bombesin (BBS) is a tetra-decapeptide amino acid neuropeptide in central nervous system within a variety of mammalian species. Also it has many biological effects that may be effective in modulation of anxiety.
AA Vafaei, AA Taherian, A Rashidy-Pour
doaj  

Comparison of Various Dosages of Escitalopram on Anxiety-like Behavior and Body Weight in Male Rats under Severe Chronic Stress

Advanced Biomedical Research
Background: Stress and escitalopram impact mood and various physiological systems. The present study aimed to compare the protective effects of different dosages of escitalopram on anxiety-like behavior and body weight in male rats subjected to severe ...
Maryam Radahmadi, Zahra Farahbakhsh
doaj   +1 more source

Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons [PDF]

, 2017
The mechanisms underlying social dysfunction in neuropsychiatric conditions like obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) remain uncertain. Dysfunctions in basal ganglia, including reduced number of striatal cholinergic interneurons
Beccaria, Juan Pablo, Belforte, Juan Emilio, Braz, Bárbara Yael, Martos Schott, Yanina Victoria, Murer, Mario Gustavo   +4 more
core   +1 more source