Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden [PDF]
, 2010 Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment.
A de Calignon +38 more
core +6 more sources
Elevated plus-maze behavior in adult offspring of selectively bred rats
Physiology & Behavior, 1996 Animals sampled from the third generation (S3) of selective breeding of N:NIH strain rats based on ultrasonic vocalization (USV) rates in infancy (High, Low, and Random lines) were tested as adults on the elevated plus maze, a well-validated test of anxiety.
G S, Dichter, S A, Brunelli, M A, Hofer
openaire +2 more sources
Bulletin of Faculty of Pharmacy Cairo University, 2014 Stress alters psychological diseases such as anxiety and depression. Protein malnutrition (PM) contributes to psychological disorders. The present study aimed to investigate the effect of biphenyl dimethyl dicarboxylate (DDB) on anxiety of ...
M.F. Sabry, M.R. Hamed, M.E. El sayed
doaj +1 more source
Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]
, 2018 BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core
The ontogeny of exploratory behavior in male and female adolescent rats (Rattus norvegicus) [PDF]
, 2009 Supported by Wellcome Trust grant 078405/Z/05/ZDuring adolescence, rats gain independence from their mothers and disperse from the natal burrow, with males typically dispersing further than females. We predicted that, if dispersal patterns are associated
Aguilar +50 more
core +2 more sources
Dorsal Hippocampus ERK2 Signaling Mediates Anxiolytic-Related Behavior in Male Rats
Chronic Stress, 2019 Background Anxiety disorders are the most common neuropathologies worldwide, but the precise neuronal mechanisms that underlie these disorders remain unknown.
Jorge A. Sierra-Fonseca +5 more
doaj +1 more source
Effect of benzene on the cerebellar structure and behavioral characteristics in rats
Asian Pacific Journal of Tropical Biomedicine, 2015 Objective: To investigate the effects of benzene on rat's cerebellum structure and behavioral characteristics, including anxiety and motor impairment.
Ali Rafati +3 more
doaj +1 more source
Primary Blast Traumatic Brain Injury in the Rat: Relating Diffusion Tensor Imaging and Behavior [PDF]
, 2013 The incidence of traumatic brain injury (TBI) among military personnel is at its highest point in U.S. history. Experimental animal models of blast have provided a wealth of insight into blast injury.
Budde, Matthew D. +5 more
core +2 more sources
Pharmacological effect of one icv dose of Allopregnanolone in female rat: behavioural profile [PDF]
, 2015 We have previously observed that intracerebroventricular allopregnanolone (ALLO) injection produced an anxiolytic effect and inhibited sexual receptivity when the test was performed in a separate manner. Also, ALLO reverts learning deficit in female rats
Cabrera Kreiker, Ricardo Jorge +5 more
core
Bioactivity guided isolation of apigenin from Stachys lavandulifolia Vahl. in mice with anxiolytic effects [PDF]
Journal of HerbMed Pharmacology, 2018 Introduction: Stachys lavandulifolia is traditionally used for the treatment of anxiety. Our previous study showed that the ethyl acetate fraction of the plant had substantial anxiolytic action in mice. The present study was aimed to investigate the main
Mohammad Rabbani +3 more
doaj +1 more source