Basic and Clinical Neuroscience, 2011 Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway.
Siamak Shahidi +2 more
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Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness [PDF]
, 2019 Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits.
Blair, Robert +3 more
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Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
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Study of the effect of extract of Thymus vulgaris on anxiety in male rats
Journal of Traditional and Complementary Medicine, 2016 There is some evidence in traditional medicine for the effectiveness of Thymus vulgaris (百里香 bǎi lǐ xiāng) in the treatment of anxiety in humans. The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds.
Alireza Komaki +3 more
doaj +1 more source
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior [PDF]
, 2015 Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a ...
Borevitz, Justin O. +13 more
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Stressor- and Corticotropin releasing Factor-induced Reinstatement and Active Stress-related Behavioral Responses are Augmented Following Long-access Cocaine Self-administration by Rats [PDF]
, 2008 Rationale Stressful events during periods of drug abstinence likely contribute to relapse in cocaine-dependent individuals. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing
AM Basso +62 more
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Alprazolam modifies animal behaviour on elevated plus-maze.
Indian journal of experimental biology, 1994 Exposure to elevated plus-maze is known to evoke approach-avoidance conflict behaviour and anxiety related movements in mice. Alprazolam (0.1 to 1 mg/kg, ip) produced dose dependant increase in antianxiety response, 100% first preference to open arm, open arm entries and exploratory behaviour.
S K, Kulkarni, K, Sharma
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Early handling and repeated cross-fostering have opposite effect on mouse emotionality [PDF]
, 2015 Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders.
Battaglia, M +6 more
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THE EFFECTS OF FLUOXETINE IN THE ELEVATED PLUS MAZE TEST
Psychiatry and Clinical Psychopharmacology, 2021 W e have studied the effects of fluoxetine, a selective serotonin reuptake inhibitor, on anxiety by using elevated plus m aze tc in m ice. A cute intraperitoneal adm inistration of fluoxetine (20 m g/kg) decreased the time spent in the open arm s ...
Mehmet KURT +3 more
doaj
Elevated plus maze test for mice v1
The elevated plus maze is a classical test to screen anxiety-like behaviors in laboratory animals. This protocol is optimized to mice. The protocol also describes the use of Biobserve Viewer, which is is a software to track online the movement of animals.
Csilla Novák +2 more
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