یافتههای نوین در علوم زیستی, 2017 Tarragon (Artemisia dracunculus L.) has antioxidant, anti-diabetic, anti-bacterial and anti-inflammatory proper-ties. The aim of this study was to evaluate the effect of tarragon hydro-alcoholic extract on anxiety and depression in male rats exposed to ...
Hajar Khosravi +2 more
doaj
Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders. [PDF]
, 2016 The laboratory rat is emerging as an attractive preclinical animal model of autism spectrum disorder (ASD), allowing investigators to explore genetic, environmental and pharmacological manipulations in a species exhibiting complex, reciprocal social ...
Bauman, Melissa D +4 more
core +3 more sources
Study of the effect of extract of Thymus vulgaris on anxiety in male rats
Journal of Traditional and Complementary Medicine, 2016 There is some evidence in traditional medicine for the effectiveness of Thymus vulgaris (百里香 bǎi lǐ xiāng) in the treatment of anxiety in humans. The elevated plus-maze (EPM) has broadly been used to investigate anxiolytic and anxiogenic compounds.
Alireza Komaki +3 more
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Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator [PDF]
, 2018 We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel ...
Joseph, Ancy +3 more
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Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness [PDF]
, 2019 Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits.
Blair, Robert +3 more
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Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze [PDF]
, 2012 The role of the histamine H3 receptor (H3R) in anxiety is controversial, due to limitations in drug selectivity and limited validity of behavioral tests used in previous studies. In the present report, we describe two experiments.
Abuhamdah, Rushdie M. +4 more
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Alprazolam modifies animal behaviour on elevated plus-maze.
Indian journal of experimental biology, 1994 Exposure to elevated plus-maze is known to evoke approach-avoidance conflict behaviour and anxiety related movements in mice. Alprazolam (0.1 to 1 mg/kg, ip) produced dose dependant increase in antianxiety response, 100% first preference to open arm, open arm entries and exploratory behaviour.
S K, Kulkarni, K, Sharma
openaire +1 more source
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior [PDF]
, 2015 Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a ...
Borevitz, Justin O. +13 more
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modCHIMERA: A novel murine closed-head model of moderate traumatic brain injury [PDF]
, 2018 Traumatic brain injury is a major source of global disability and mortality. Preclinical TBI models are a crucial component of therapeutic investigation.
Bayly, P. V. +7 more
core +2 more sources
Anxiolytic effect of methylene blue microinjected into the dorsal periaqueductal gray matter
Brazilian Journal of Medical and Biological Research, 1999 The dorsal periaqueductal gray (DPAG) has been implicated in the behavioral and autonomic expression of defensive reactions. Several results suggest that, along with GABA, glutamate and serotonin, nitric oxide (NO) may play a role in defense reactions ...
R.W. de-Oliveira, F.S. Guimarães
doaj +1 more source