Results 71 to 80 of about 2,582,481 (333)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Remote sensing and GIS-based forest fire risk zone mapping: The case of Manisa, Turkey

open access: yesTurkish Journal of Forestry, 2020
The aim of this research is to map the potential forest fire risk zones using various landscape analysis techniques in Manisa province, Turkey. Forest fire, which is defined as an ecological disaster caused by natural processes or as a result of human ...
Derya GÜLÇİN, Bülent DENİZ
doaj   +1 more source

Farming Differentiation in the Rural-urban Interface of the Middle Mountains, Nepal: Application of Analytic Hierarchy Process (AHP)Modeling [PDF]

open access: yes, 2010
This article investigates the dominant factors of farming differentiation in the rural-urban interface of the densely populated Kathmandu Valley, using the Analytic Hierarchy Process (AHP) modeling. The rural-urban interface in the Kathmandu Valley is
Bhatta, G.D., Doppler, W.
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Flood hazards under changing climate: applying an analytical hierarchy process in the Mazam-Watrak River Basin, India

open access: yesH2Open Journal, 2023
In this study, the coupling of the analytical hierarchy process (AHP) and geographical information system (GIS) was used to assess flood hazards. Spatial analysis in the GIS environment has been applied for the estimation of flood hazard zones in which ...
Payal Makhasana, Geeta S. Joshi
doaj   +1 more source

A multidisciplinary coastal vulnerability assessment for local government focused on ecosystems, Santa Barbara area, California [PDF]

open access: yes, 2019
Incorporating coastal ecosystems in climate adaptation planning is needed to maintain the well-being of both natural and human systems. Our vulnerability study uses a multidisciplinary approach to evaluate climate change vulnerability of an urbanized ...
Myers, Monique
core  

Enhanced lake elevation mapping using a zone-based method

open access: yesEnvironmental Research Letters
Abstract Inland lakes play a crucial role in monitoring global climate change and managing responses to extreme weather events, with lake elevation being critical for assessing their regulatory capacities. However, due to the limited temporal resolution of current altimetry satellites, obtaining high-frequency, high-precision elevation ...
Meiyi Fan   +8 more
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

\u27How To\u27 Guide for Synthesizing NERRs Marsh Monitoring Data [PDF]

open access: yes, 2020
The purpose of this guide is to provide a user-friendly and informative guide on ‘How to’ synthesize salt marsh data from theNational Estuarine Research Reserve System (NERRs).
Burdick, David M
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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