Results 51 to 60 of about 687,033 (246)

Understanding Long COVID Among Young People in Victoria, Australia: Prevalence, Impact, and Associated Factors

Public Health Challenges
Introduction Long COVID is a significant public health concern. This study aimed to identify the prevalence, impact, and factors associated with long COVID among young people in Victoria, Australia.
Robin Engelberts, Caitlin H. Douglass, Ana Orozco, Sarah Eddy, Anna Lee Wilkinson, Aimée Altermatt, Suzanne van denToren, Megan S. C. Lim   +7 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model

Malaria Journal, 2018
Background Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low transmission, but has yet to be reported in Africa.
Nick Scott, Ricardo Ataide, David P. Wilson, Margaret Hellard, Ric N. Price, Julie A. Simpson, Freya J. I. Fowkes   +6 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Insecticide-treated nets mass distribution campaign: benefits and lessons in Zambia

Malaria Journal, 2018
Background Zambia was an early adopter of insecticide-treated nets strategy in 2001, and policy for mass distribution with long-lasting insecticidal nets (LLINs) in 2005. Since then, the country has implemented mass distribution supplemented with routine
Freddie Masaninga, Nawa Mukumbuta, Ketty Ndhlovu, Busiku Hamainza, Pauline Wamulume, Emmanuel Chanda, John Banda, Mercy Mwanza-Ingwe, John M. Miller, Birkinesh Ameneshewa, Abraham Mnzava, Elizabeth Kawesha-Chizema   +11 more
doaj   +1 more source

Cut-elimination and Redundancy-elimination by Resolution

Journal of Symbolic Computation, 2000
The authors propose a new cut-elimination procedure for classical predicate calculus LK. The basic formulation treats a particular case: \[ \text{if }A,\Gamma\vdash\Delta\text{ is derivable and }A\text{ is valid, then }\Gamma\vdash\Delta\text{ is derivable}.\tag{\(*\)} \] In general a cut like \(\Gamma\vdash B\); \(B,\Gamma\vdash\Delta/\Gamma \vdash ...
Baaz, Matthias, Leitsch, Alexander
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The use of spatial and genetic tools to assess Plasmodium falciparum transmission in Lusaka, Zambia between 2011 and 2015

Malaria Journal, 2020
Background Zambia has set itself the ambitious target of eliminating malaria by 2021. To continue tracking transmission to zero, new interventions, tools and approaches are required.
Daniel J. Bridges, Sandra Chishimba, Mulenga Mwenda, Anna M. Winters, Erik Slawsky, Brenda Mambwe, Conceptor Mulube, Kelly M. Searle, Aves Hakalima, Roy Mwenechanya, David A. Larsen   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Patients’ experience of accessing hepatitis C treatment through the Myanmar national hepatitis C treatment program: a qualitative evaluation

BMC Health Services Research
Background Globally, 56.8 million people are living with hepatitis C and over three-quarters of those reside in low and middle-income countries (LMICs). Barriers and enablers to hepatitis C care among people who inject drugs in high-income countries are ...
Bridget Draper, Win Lei Yee, Anna Bowring, Win Naing, Khin Pyone Kyi, Hla Htay, Jessica Howell, Margaret Hellard, Alisa Pedrana   +8 more
doaj   +1 more source