Results 51 to 60 of about 2,298,074 (328)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Health systems readiness and quality of inpatient malaria case-management in Kano State, Nigeria
Malaria Journal, 2020 Background Nigeria was among the first African countries to adopt and implement change of treatment policy for severe malaria from quinine to artesunate.
Abiodun A. Ojo +11 more
doaj +1 more source
Cut-elimination for the modal Grzegorczyk logic via non-well-founded proofs
, 2017 We present a sequent calculus for the modal Grzegorczyk logic Grz allowing non-well-founded proofs and obtain the cut-elimination theorem for it by constructing a continuous cut-elimination mapping acting on these proofs.Comment: WOLLIC'17, 12 pages, 1 ...
A Avron +5 more
core +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Photoinitiated oxidative addition of CF3I to gold(I) and facile aryl-CF3 reductive elimination. [PDF]
, 2014 Herein we report the mechanism of oxidative addition of CF3I to Au(I), and remarkably fast Caryl-CF3 bond reductive elimination from Au(III) cations. CF3I undergoes a fast, formal oxidative addition to R3PAuR (R = Cy, R = 3,5-F2-C6H4, 4-F-C6H4, C6H5, 4 ...
TOSTE, F. Dean +2 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Incidence and management of patients with methotrexate delayed elimination in the clinical practice: A Delphi study [PDF]
, 2022 Luis Gros +11 more
openalex +1 more source
Efficacy Evaluation of the Phytotherapeutic Drug Canephron N in the Complex Treatment of Patients with Urolithiasis Using Extracorporeal Shock Wave Lithotripsy [PDF]
, 2018 The study objective was to analyse the effect of the herbal drug Canephron N, namely, its ability to potentiate the efficacy of extracorporeal shock wave lithotripsy (ESWL) in the treatment of patients with urolithiasis (UL) and prevent recurrence of ...
Vitkovskyy, V. (Volodymir)
core +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
International Journal of Adolescence and YouthThis study aimed to understand how COVID-19 affected social connection, barriers to connection, and generated ideas for creating pro-connection activities and spaces.
Megan S. C. Lim +3 more
doaj +1 more source