Results 61 to 70 of about 2,298,074 (328)

Outlook for tuberculosis elimination in California: An individual-based stochastic model. [PDF]

, 2019
RationaleAs part of the End TB Strategy, the World Health Organization calls for low-tuberculosis (TB) incidence settings to achieve pre-elimination (<10 cases per million) and elimination (<1 case per million) by 2035 and 2050, respectively. These
Barry, Pennan M, Cattamanchi, Adithya, Flood, Jennifer, Goodell, Alex J, Hill, Andrew, Kahn, James G, Marks, Suzanne M, McCabe, Devon, Porco, Travis C, Shete, Priya B, Vreman, Rick   +10 more
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A semi-field evaluation in Thailand of the use of human landing catches (HLC) versus human-baited double net trap (HDN) for assessing the impact of a volatile pyrethroid spatial repellent and pyrethroid-treated clothing on Anopheles minimus landing

Malaria Journal, 2023
Background The mosquito landing rate measured by human landing catches (HLC) is the conventional endpoint used to evaluate the impact of vector control interventions on human-vector exposure.
Élodie A. Vajda, Manop Saeung, Amanda Ross, David J. McIver, Allison Tatarsky, Sarah J. Moore, Neil F. Lobo, Theeraphap Chareonviriyaphap   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Costing analysis of a Queensland community corrections hepatitis C screening program

BMC Health Services Research
Background People involved with the criminal justice system typically have lower healthcare engagement and higher risk of hepatitis C virus (HCV) infection than the general population. Interventions run at community corrections centres have the potential
Kelly Maynard, Farah Houdroge, Rachael Thompson, Anna L. Hawkes, Alisa Pedrana, Jacqueline A. Richmond, Nick Scott   +6 more
doaj   +1 more source

On Computing the Elimination Ideal Using Resultants with Applications to Gr\"obner Bases [PDF]

, 2015
Resultants and Gr\"obner bases are crucial tools in studying polynomial elimination theory. We investigate relations between the variety of the resultant of two polynomials and the variety of the ideal they generate.
Gallet, Matteo, Rahkooy, Hamid, Zafeirakopoulos, Zafeirakis   +2 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model

Malaria Journal, 2018
Background Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low transmission, but has yet to be reported in Africa.
Nick Scott, Ricardo Ataide, David P. Wilson, Margaret Hellard, Ric N. Price, Julie A. Simpson, Freya J. I. Fowkes   +6 more
doaj   +1 more source

Updated epidemiology of hepatitis C virus infections and implications for hepatitis C virus elimination in Germany [PDF]

, 2022
Tammo Lambert Tergast, Sarah Blach, Frank Tacke, Thomas Berg, Markus Cornberg, Achim Kautz, Michael P. Manns, Homie Razavi, Christoph Sarrazin, Yvonne Serfert, Ingo van Thiel, Stefan Zeuzem, Heiner Wedemeyer   +12 more
openalex   +1 more source