Results 81 to 90 of about 912,001 (286)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Elongation of confined ferrofluid droplets under applied fields

, 1999
Ferrofluids are strongly paramagnetic liquids. We study the behavior of ferrofluid droplets confined between two parallel plates with a weak applied field parallel to the plates. The droplets elongate under the applied field to reduce their demagnetizing
A. W. Adamson, C. Flament, G. A. Flores, H. Li, J. Bibette, J. C. Bacri, J. C. Bacri, J. Liu, M. Fasnacht, M. Widom, R. E. Rosensweig, R. E. Rosensweig, S. A. Langer, S. Banerjee, S. Garoff, V. G. Bashtovoi, V. I. Arkhipenko, V. I. Drozdova, W. F. Brown   +18 more
core   +1 more source

A link between transcription fidelity and pausing in vivo [PDF]

, 2017
Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source
Gamba, Pamela, James, Katherine, Zenkin, Nikolay   +2 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The Influence of Molecular Adsorption on Elongating Gold Nanowires

, 2011
Using molecular dynamics simulations, we study the impact of physisorbing adsorbates on the structural and mechanical evolution of gold nanowires (AuNWs) undergoing elongation.
Andrews D. Q., Bilic A., Bogozi A., Cafe P. F., Chen F., Christopher R. Iacovella, Cleri F., Coura P., Dubois L., Frenkel D., Guo S., He H., Heinz H., Hostetler M., Huo Z., Jayaraman A., Jayaraman A., Jimenez A., Jorgensen W., Kim H. S., Koh S. J. A., Kondo Y., Kondo Y., Krishna R., Leach A. R., Lin J., Lu Y., Marszalek P., Oshima Y., Pan N., Paulsson M., Peter T. Cummings, Piana S., Plimpton S., Pontes R. B., Pu Q., Pu Q., Pu Q., Pu Q., Rappe A., Reed M., Rodrigues V., Rodrigues V., Rubio G., Sato F., Scheer E., Schneebeli S. T., Sergueev N., Shi P., Singh C., Strange M., Tsutsui M., Tsutsui M., Tsutsui M., Velez P., Wang B., Wang D., Weinberger C. R., Wen Y.-H., William R. French, Wu S., Xu J., Yang A.-C., Yanson A.   +63 more
core   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Spatial Constraint Corrections to the Elasticity of dsDNA Measured with Magnetic Tweezers [PDF]

, 2007
In this paper, we have studied, within a discrete WLC model, the spatial constraints in magnetic tweezers used in single molecule experiments. Two elements are involved: first, the fixed plastic slab on which is stuck the initial strand, second, the ...
Bicout D J, Bouchiat C, Bouchiat C, Bouchiat C, Burkhardt T W, Burkhardt T W, C Bouchiat, Freed K L, Kierfeld J, Maggs A C, Yamakawa H   +10 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Ellipticity of Structures in CMB Sky Maps

, 2010
We study the ellipticity of contour lines in the sky maps of the cosmic microwave background (CMB) as well as other measures of elongation. The sensitivity of the elongation on the resolution of the CMB maps which depends on the pixelization and the beam
FRANK STEINER, Gurzadyan V. G., Gurzadyan V. G., HOLGER S. JANZER, Prudnikov A. P., RALF AURICH, SVEN LUSTIG   +6 more
core   +1 more source