Results 41 to 50 of about 3,972 (282)

Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy

Journal of Experimental & Clinical Cancer Research, 2021
Background Gallbladder cancer (GBC) is known for its high malignancy and multidrug resistance. Previously, we uncovered that impaired integrity and stability of the elongator complex leads to GBC chemotherapy resistance, but whether its restoration can ...
Sunwang Xu, Cen Jiang, Ruirong Lin, Xiaopeng Wang, Xiaoqiang Hu, Wei Chen, Xiangjin Chen, Tao Chen   +7 more
doaj   +1 more source

tRNA binding to Kti12 is crucial for wobble uridine modification by Elongator. [PDF]

Nucleic Acids Res
In yeast, tRNA modifications that are introduced by the Elongator complex are recognized by zymocin, a fungal tRNase killer toxin that cleaves the anticodon.
Scherf D, Hammermeister A, Böhnert P, Burkard A, Helm M, Glatt S, Schaffrath R.   +6 more
europepmc   +2 more sources

T‐armless tRNAs and elongated elongation factor Tu [PDF]

IUBMB Life, 2007
AbstractMost tRNAs share a common secondary structure containing a T arm, a D arm, an anticodon arm and an acceptor stem. However, there are some exceptions. Most nematode mitochondrial tRNAs and some animal mitochondrial tRNAs lack the T arm, which is necessary for binding to canonical elongation factor Tu (EF‐Tu).
Takashi, Ohtsuki, Yoh-ichi, Watanabe
openaire   +2 more sources

Cosmoconus (Cosmoconus) elongator

, 2008
Cosmoconus (Cosmoconus) elongator (FABRICIUS 1775) Ichneumon elongator FABRICIUS 1775. Syst. Ent. p. 337. Tryphon elongator: MOCSARY 1897: 46, Croatia.
Kolarov, J.
core   +1 more source

Wheat Elongator subunit 4 is required for epigenetic regulation of host immune response to Rhizoctonia cerealis

Crop Journal, 2020
Wheat (Triticum aestivum) is necessary for global food security. The necrotrophic fungus Rhizoctonia cerealis is the causal agent of sharp eyespot, a devastating disease of wheat.
Kai Wang, Wei Rong, Yuping Liu, Hui Li, Zengyan Zhang   +4 more
doaj   +1 more source

Phytodietus (Neuchorus) elongator AUBERT 1963

, 2008
Phytodietus (Neuchorus) elongator AUBERT 1963 Phytodietus elongator AUBERT 1963. Bul. Soc. Ent. France, 68 (march-april): 96, Croatia, September. D i s t r i b u t i o n:Palearcticregion.Published as part of Kolarov, J., 2008, A Catalogue of the ...
Kolarov, J.
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

SSD1 modifies phenotypes of Elongator mutants

, 2020
The translational decoding properties of tRNAs are influenced by post-transcriptional modification of nucleosides in their anticodon region. The Elongator complex promotes the first step in the formation of 5-methoxycarbonylmethyl (mcm(5)), 5 ...
Byström, Anders,, Johansson, Marcus J. O.,, Byström, Anders, Johansson, Marcus J. O., Xu, Fu,, Xu, Fu   +5 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source