Results 31 to 40 of about 3,972 (282)
Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes. [PDF]
, 2011 Eukaryotic cells limit ribosomal DNA (rDNA) transcription by RNA polymerase I (RNAP-I) to maintain genome integrity. African trypanosomes present an excellent model for studies on RNAP-I regulation because they possess a bifunctional RNAP-I and because ...
Horn, David +4 more
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Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. [PDF]
PLoS Genetics, 2009 Elongator is a six subunit protein complex, conserved from yeast to humans. Mutations in the human Elongator homologue, hELP1, are associated with the neurological disease familial dysautonomia.
Changchun Chen +2 more
doaj +1 more source
Elongational Stresses and Cells [PDF]
Cells, 2021 Fluid forces and their effects on cells have been researched for quite some time, especially in the realm of biology and medicine. Shear forces have been the primary emphasis, often attributed as being the main source of cell deformation/damage in devices like prosthetic heart valves and artificial organs.
Kylie M. Foster +2 more
openaire +4 more sources
The Arabidopsis ELP3/ELO3 and ELP4/ELO1 genes enhance disease resistance in Fragaria vesca L.
BMC Plant Biology, 2017 Background Plant immune response is associated with a large-scale transcriptional reprogramming, which is regulated by numerous transcription regulators such as the Elongator complex.
Katchen Julliany P. Silva +5 more
doaj +1 more source
PLoS Pathogens, 2022 The eukaryotic multisubunit Elongator complex has been shown to perform multiple functions in transcriptional elongation, histone acetylation and tRNA modification.
Yuanwei Zhang +4 more
doaj +1 more source
PLoS Genetics, 2009 Histone chaperones CAF-1 and Asf1 function to deposit newly synthesized histones onto replicating DNA to promote nucleosome formation in a proliferating cell nuclear antigen (PCNA) dependent process.
Qing Li +5 more
doaj +1 more source
Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification. [PDF]
PLoS Genetics, 2011 Elongator complex is required for formation of the side chains at position 5 of modified nucleosides 5-carbamoylmethyluridine (ncm⁵U₃₄), 5-methoxycarbonylmethyluridine (mcm⁵U₃₄), and 5-methoxycarbonylmethyl-2-thiouridine (mcm⁵s²U₃₄) at wobble position in
Changchun Chen +4 more
doaj +1 more source
MYC in elongation and repression [PDF]
Nature Reviews Cancer, 2018 Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc.
openaire +3 more sources
Frontiers in Cellular Neuroscience, 2017 The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective α-tubulin acetylation.
Sophie Laguesse +12 more
doaj +1 more source
Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs. [PDF]
PLoS Genetics, 2013 The Elongator complex, including the histone acetyl transferase Sin3/Elp3, was isolated as an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display transcriptional defects. However, it has also been shown that Elongator
Jorge Fernández-Vázquez +10 more
doaj +1 more source