Results 11 to 20 of about 3,972 (282)

Research progress of the Elongator complex in plant [PDF]

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2023
The Elongator complex consists of six subunits (ELP1-ELP6), where ELP1-ELP3 forms the core subcomplex and ELP4-ELP6 forms the auxiliary subcomplex. Deletion of any of the six subunits results in an almost identical phenotype, suggesting that all six ...
Ji XIANGZHUO, Zhuang ZELONG, Wang YINXIA, Zhang YUNFANG, Peng YUNLING   +4 more
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Translational Control of Cell Division by Elongator [PDF]

Cell Reports, 2012
Elongator is required for the synthesis of the mcm5s2 modification found on tRNAs recognizing AA-ending codons. In order to obtain a global picture of the role of Elongator in translation, we used reverse protein arrays to screen the fission yeast ...
Fanelie Bauer, Akihisa Matsuyama, Julie Candiracci, Marc Dieu, Judith Scheliga, Dieter A. Wolf, Minoru Yoshida, Damien Hermand   +7 more
doaj   +2 more sources

Elongator and the role of its subcomplexes in human diseases [PDF]

EMBO Molecular Medicine, 2022
The Elongator complex was initially identified in yeast, and a variety of distinct cellular functions have been assigned to the complex. In the last decade, several research groups focussed on dissecting its structure, tRNA modification activity and role
Monika Gaik, Marija Kojic, Brandon J Wainwright, Sebastian Glatt   +3 more
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Initiation with Elongator tRNAs [PDF]

Journal of Bacteriology, 2013
In all domains of life, initiator tRNA functions exclusively at the first step of protein synthesis while elongator tRNAs extend the polypeptide chain. Unique features of initiator tRNA enable it to preferentially bind the ribosomal P site and initiate translation.
Laasya, Samhita, Kai, Virumäe, Jaanus, Remme, Umesh, Varshney   +3 more
openaire   +3 more sources

Elongator and its epigenetic role in plant development and responses to abiotic and biotic stresses [PDF]

Frontiers in Plant Science, 2015
Elongator, a six-subunit protein complex, was initially isolated as an interactor of hyperphosphorylated RNA polymerase II in yeast, and was subsequently identified in animals and plants.
Yezhang eDing, Zhonglin eMou
doaj   +2 more sources

The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.

PLoS Genetics, 2010
Although acetylated alpha-tubulin is known to be a marker of stable microtubules in neurons, precise factors that regulate alpha-tubulin acetylation are, to date, largely unknown.
Jachen A Solinger, Roberta Paolinelli, Holger Klöss, Francesco Berlanda Scorza, Stefano Marchesi, Ursula Sauder, Dai Mitsushima, Fabrizio Capuani, Stephen R Stürzenbaum, Giuseppe Cassata   +9 more
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The Elongator Complex Negatively Regulates Polarized Secretion [PDF]

, 2007
Intracellular transport is fundamental for eukaryotic life and the function of regulators of transport is evolutionarily conserved. Rab proteins are a family of key regulators of vesicle and organelle transport, which aid in cell proliferation and cell ...
Rahl, Peter
core   +6 more sources

Germline Elongator mutations in Sonic Hedgehog medulloblastoma. [PDF]

, 2020
Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear.
Smith, Kyle S., Feychting, Maria, Smith, Kyle S, Chintagumpala, Murali, Wainwright, Brandon J., Ellison, David W., Dufour, Christelle, Gudenas, Brian L., Orr, Brent A, Korshunov, Andrey, Smith, Amy, Rusch, Michael, Kuehni, Claudia, Sharma, Tanvi, Ellison, David W, Grotzer, Michael, Nichols, Kim E., Jones, David, Hadley, Jennifer, Vasilyeva, Aksana, Kjaerheim, Kristina, Jäger, Natalie, Andersen, Tina V, Ellison, David, Lannering, Birgitta, Lombard, Bérangère, Andersen, Tina V., Bowers, Daniel C, Pfister, Stefan M, Pfister, Stefan, Nichols, Kim, Northcott, Paul, Gottardo, Nicholas, Tatevossian, Ruth G., Gajjar, Amar, Northcott, Paul A, Nakitandwe, Joy, Robinson, Giles, Puget, Stéphanie, Hamilton, Kayla V, Kuehni, Claudia E., Rausch, Tobias, Kool, Marcel, Wesenberg, Finn, Lichter, Peter, Korbel, Jan O, Sturm, Dominik, Buchhalter, Ivo, Gudenas, Brian, Partap, Sonia, Tatevossian, Ruth G, Northcott, Paul A., Rutkowski, Stefan, Orr, Brent A., Witt, Olaf, Smith, Kyle, Loew, Damarys, Ryzhova, Marina, Wainwright, Brandon J, Hamilton, Kayla V., Pfister, Stefan M., Garcia-Lopez, Jesus, Jones, David T W, Milde, Till, Eggen, Tone, Korbel, Jan, Waszak, Sebastian M, Pajtler, Kristian, Brugieres, Laurence, Röösli, Martin, Orr, Brent, Neale, Geoffrey, Bendel, Anne, Wainwright, Brandon, Hamilton, Kayla, Jones, David T.W., Gudenas, Brian L, Pajtler, Kristian W., Korbel, Jan O., Andersen, Tina, Kojic, Marija, Indersie, Emilie, Tatevossian, Ruth, Forget, Antoine, Robinson, Giles W, Gottardo, Nicholas G, Bowers, Daniel C., Waszak, Sebastian M., Remke, Marc, Nichols, Kim E, Bowers, Daniel, Jones, David T. W., Kerssemakers, Jules, Waszak, Sebastian, Johansen, Christoffer, Robinson, Giles W., Pajtler, Kristian W, Ayrault, Olivier, Crawford, John, Gottardo, Nicholas G., Schüz, Joachim   +100 more
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Cryo-EM structure of the fully assembled elongator complex [PDF]

, 2023
Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during protein synthesis. All known tRNAs are heavily modified at multiple positions through post-transcriptional addition of chemical groups. Modifications in the tRNA anticodons
Hammermeister, Alexander, Lin, Ting-Yu, Indyka, Paulina, Dobosz, Dominika, Scherf, David, Rawski, Michał, Rappsilber, Juri, Chramiec-Głąbik, Andrzej, Jaciuk, Marcin, Rau, Alexander, Schaffrath, Raffael, Graziadei, Andrea, Biela, Anna, Kosinski, Jan, Krutyhołowa, Rościsław, Kaszuba, Karol, Gaik, Monika, Abbassi, Nour El Hana, Glatt, Sebastian, Kościelniak, Anna, Abbassi, Nour-El-Hana   +20 more
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Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway

Biology Open, 2021
Elongator dysfunction is increasingly recognized as a contributor to multiple neurodevelopmental and neurodegenerative disorders including familial dysautonomia, intellectual disability, amyotrophic lateral sclerosis, and autism spectrum disorder ...
BreAnna Cameron, Elin Lehrmann, Tien Chih, Joseph Walters, Richard Buksch, Sara Snyder, Joy Goffena, Frances Lefcort, Kevin G. Becker, Lynn George   +9 more
doaj   +1 more source