Results 1 to 10 of about 3,972 (282)

Elongator is a microtubule polymerase selective for polyglutamylated tubulin [PDF]

EMBO Journal
Elongator is a tRNA-modifying complex that regulates protein translation. Recently, a moonlighting function of Elongator has been identified in regulating the polarization of the microtubule cytoskeleton during asymmetric cell division. Elongator induces
Carsten Janké, Lara K Kruger, Alice Bittleston   +2 more
exaly   +11 more sources

Cryo-EM structures of the human Elongator complex at work [PDF]

Nature Communications
tRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-carboxymethyl at wobble uridine bases (cm5U34) in eukaryotic tRNAs.
Nour-el-Hana Abbassi, Marcin Jaciuk, David Scherf, Pauline Böhnert, Alexander Rau, Alexander Hammermeister, Michał Rawski, Paulina Indyka, Grzegorz Wazny, Andrzej Chramiec-Głąbik, Dominika Dobosz, Bozena Skupien-Rabian, Urszula Jankowska, Juri Rappsilber, Raffael Schaffrath, Ting-Yu Lin, Sebastian Glatt   +16 more
doaj   +3 more sources

Functional divergence of the two Elongator subcomplexes during neurodevelopment

EMBO Molecular Medicine, 2022
The highly conserved Elongator complex is a translational regulator that plays a critical role in neurodevelopment, neurological diseases, and brain tumors.
Tulay Oncu Oner, Marija Kojic, Saadet Mercimek-Mahmutoglu   +2 more
exaly   +2 more sources

Leishmania donovani elongator protein Elp3a plays a crucial role in modulating the parasite response to genotoxic stress [PDF]

Microbiology Spectrum
The eukaryotic elongator complex comprises six proteins Elp1–Elp6, with Elp3 being the catalytic subunit. In trypanosomatids, only Elp3 has been identifiable, and interestingly, these organisms have two Elp3 orthologs: Elp3a and Elp3b.
Arushi Khanna, Shilpa Rohra, Swati Saha
doaj   +2 more sources

Recent Advances in the Role of the Elongator Complex in Plant Physiology and tRNA Modification: A Review

Journal of Integrative Agriculture, 2014
The Elongator complex is a multifunction protein complex which has been shown to be involved in transcriptional elongation, DNA replication and repair, tubulin and histone acetylation, gene silencing and tranfer RNA uridine modification.
Bo Zheng
exaly   +3 more sources

An Elongator mouse model of ALS spotlights TDP-43 in the motor neuron nucleolus [PDF]

Communications Biology
Dysfunction of Elongator is associated with amyotrophic lateral sclerosis (ALS). Here, we describe mouse models in which either Elongator subunit 1(Elp1) or subunit 3 (Elp3) is selectively ablated in alpha motor neurons of the spinal cord.
Magge Snow, BreAnna Cameron, Renzie Pond, Rachel Trudell, Sara Snyder, Lauryn Torres-Hernandez, Devyn Deschamps, Danara Tulimaiau, Kiana Hawkinson, Morgan Russell, Danielle Horan, Joseph Walters, James H. Fox, Britni Arlian, Alain Chariot, Laurent Nguyen, Lynn George   +16 more
doaj   +2 more sources

Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator

Toxins, 2017
Saccharomyces cerevisiae cells are killed by zymocin, a tRNase ribotoxin complex from Kluyveromyces lactis, which cleaves anticodons and inhibits protein synthesis.
Alexander Hammermeister, Stark M J R, Raffael Schaffrath   +2 more
exaly   +3 more sources

The Many Faces of Elongator in Neurodevelopment and Disease

Frontiers in Molecular Neuroscience, 2016
Development of the nervous system requires a variety of cellular activities, such as proliferation, migration, axonal outgrowth and guidance and synapse formation during the differentiation of neural precursors into mature neurons.
Marija Kojic, Brandon Wainwright
exaly   +3 more sources

E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development [PDF]

Nature Communications
Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood.
Michela Di Michele, Aurore Attina, Pierre-François Roux, Imène Tabet, Sophie Laguesse, Javier Florido, Morane Houdeville, Armelle Choquet, Betty Encislai, Giuseppe Arena, Carlo De Blasio, Olivia Wendling, François-Xavier Frenois, Laura Papon, Lucille Stuani, Maryse Fuentes, Céline Jahannault Talignani, Mélanie Rousseau, Justine Guégan, Yoan Buscail, Pierrick Dupré, Henri-Alexandre Michaud, Geneviève Rodier, Floriant Bellvert, Hanna Kulyk, Carole Ferraro Peyret, Hugo Mathieu, Pierre Close, Francesca Rapino, Cédric Chaveroux, Nelly Pirot, Lucie Rubio, Adeline Torro, Tania Sorg, Fabrice Ango, Christophe Hirtz, Vincent Compan, Elise Lebigot, Andrea Legati, Daniele Ghezzi, Laurent Nguyen, Alexandre David, Claude Sardet, Matthieu Lacroix, Laurent Le Cam   +44 more
doaj   +2 more sources

Leiomodin 2 is a processive pointed-end elongator of actin filaments [PDF]

Nature Communications
The actin cytoskeleton drives essential processes like cell migration and muscle contraction. While barbed-end polymerization is well-established, pointed-end elongation was long considered impossible in vivo. Here, we demonstrate that Leiomodin 2 (Lmod2)
Sudipta Biswas, Tania M. Larrinaga, Sandeep Choubey, Carol C. Gregorio, Shashank Shekhar   +4 more
doaj   +2 more sources