Prime editing of the common Familial Dysautonomia-causing c.2204 + 6T > C splicing mutation. [PDF]
Orphanet J Rare DisPeretto L, Pinotti M, Balestra D.
europepmc +1 more source
Upregulation of ELP3 in acinar cells during acute pancreatitis is dispensable for homeostasis, inflammation, regeneration, and cancer initiation. [PDF]
Sci RepAajja E +11 more
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Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology. [PDF]
Cell Death DisWang H, Zhang J, Jiang C, Xu S.
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Structures and Activities of the Elongator Complex and Its Cofactors
The Enzymes, 2017 Elongator is a highly conserved eukaryotic protein complex consisting of two sets of six Elp proteins, while homologues of its catalytic subunit Elp3 are found in all the kingdoms of life. Although it was originally described as a transcription elongation factor, cumulating evidence suggests that its primary function is catalyzing tRNA modifications ...
Bertrand Séraphin
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Elongator, a conserved complex required for wobble uridine modifications in Eukaryotes
RNA Biology, 2014 Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The role of this complex has been controversial as the pleiotropic phenotypes of Elongator mutants have implicated the complex in several cellular processes. However, in yeast there
Anders Bystrom +2 more
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Plant Elongator—Protein Complex of Diverse Activities Regulates Growth, Development, and Immune Responses [PDF]
International Journal of Molecular Sciences, 2020 Contrary to the conserved Elongator composition in yeast, animals, and plants, molecular functions and catalytic activities of the complex remain controversial.
Magdalena Woloszynska +1 more
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Structures of human primosome elongation complexes
Nature Structural & Molecular Biology, 2023The synthesis of RNA-DNA primer by primosome requires coordination between primase and DNA polymerase α subunits, which is accompanied by unknown architectural rearrangements of multiple domains. Using cryogenic electron microscopy, we solved a 3.6 Å human primosome structure caught at an early stage of RNA primer elongation with deoxynucleotides.
Qixiang He +7 more
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An Elongated Dihydrogen Complex of Iridium
Journal of the American Chemical Society, 2003Reaction of [Cp*Ir(dmpm)Cl]Cl with [Et3Si]B(ArF)4 (dmpm = bisdimethyl-phosphinomethane; ArF = C6F5) under hydrogen gas affords the dicationic complex [Cp*Ir(dmpm)H2]2+ (1), which is readily deprotonated by weak bases to give [Cp*Ir(dmpm)H]+. Complex 1 exists as a mixture of two isomers (97:3).
Vincent, Pons, D Michael, Heinekey
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The RNA Polymerase II Elongation Complex
Annual Review of Biochemistry, 1995▪ Abstract Synthesis of eukaryotic mRNA by RNA polymerase II is an elaborate biochemical process that requires the concerted action of a large set of transcription factors. RNA polymerase II transcription proceeds through multiple stages designated preinitiation, initiation, and elongation.
T, Aso, J W, Conaway, R C, Conaway
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