Results 111 to 120 of about 684,507 (282)
Unsupervised Learning in RSS-Based DFLT Using an EM Algorithm. [PDF]
Sensors (Basel), 2021 Kaltiokallio O +3 more
europepmc +1 more source
Advanced Science, EarlyView.This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang +9 more
wiley +1 more source
Stochastic Version of EM Algorithm for Nonlinear Random Change-Point Models. [PDF]
Proc Int Conf Stat Theory Appl ICSTA, 2021 Zhang H, Manandhar B.
europepmc +1 more source
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
Classification of disease recurrence using transition likelihoods with expectation-maximization algorithm. [PDF]
Stat Med, 2022 Jiang H, Li Q, Lin JT, Lin FC.
europepmc +1 more source
Advanced Science, EarlyView.Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann +3 more
wiley +1 more source
New Vessel Extraction Method by Using Skew Normal Distribution for MRA Images
StatsVascular-related diseases pose significant public health challenges and are a leading cause of mortality and disability. Understanding the complex structure of the vascular system and its processes is crucial for addressing these issues.
Tohid Bahrami +3 more
doaj +1 more source
Forward and Backward Bellman Equations Improve the Efficiency of the EM Algorithm for DEC-POMDP. [PDF]
Entropy (Basel), 2021 Tottori T, Kobayashi TJ.
europepmc +1 more source
ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment
Advanced Science, EarlyView.ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song +12 more
wiley +1 more source
Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations
Advanced Science, EarlyView.Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl +7 more
wiley +1 more source