Results 71 to 80 of about 104,844 (357)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Effect of sorption moisture content of heavy concrete on radon emanation
Magazine of Civil Engineering, 2020 This article provides the results of a study to determine the emanation coefficient of artificial construction material, namely heavy concrete produced by semi-dry pressing, depending on equilibrium sorption moisture content achieved in the desorption ...
Rashit Nazirov +4 more
doaj +1 more source
, 2018 This paper explores a special kind of loop of grounding: cosmic loops. A cosmic loop is a loop that intuitively requires us to go "around" the entire universe to come back to the original ground. After describing several kinds of cosmic loop scenarios,
Nolan, Daniel
core +1 more source
Radon in the DRIFT-II directional dark matter TPC: emanation, detection and mitigation [PDF]
, 2014 Radon gas emanating from materials is of interest in environmental science and also a major concern in rare event non-accelerator particle physics experiments such as dark matter and double beta decay searches, where it is a major source of background ...
J. Battat +41 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A comparative study of ethylene emanation upon nitrogen deficiency in natural accessions of Arabidopsis thaliana [PDF]
, 2016 An original approach to develop sustainable agriculture with less nitrogen fertilizer inputs is to tackle the cross-talk between nitrogen nutrition and plant growth regulators.
Cristescu, Simona M +6 more
core +1 more source
Track Reconstruction and Performance of DRIFT Directional Dark Matter Detectors using Alpha Particles [PDF]
, 2007 First results are presented from an analysis of data from the DRIFT-IIa and DRIFT-IIb directional dark matter detectors at Boulby Mine in which alpha particle tracks were reconstructed and used to characterise detector performance--an important step ...
A. Petkov +49 more
core +3 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
The BetaCage, an ultra-sensitive screener for surface contamination [PDF]
, 2013 Material screening for identifying low-energy electron emitters and alpha-decaying isotopes is now a prerequisite for rare-event searches (e.g., dark-matter direct detection and neutrinoless double-beta decay) for which surface radiocontamination has ...
Ahmed, Z. +10 more
core +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source