Results 51 to 60 of about 189,796 (264)

Quantitative Nano-characterization of Polymers Using Atomic Force Microscopy

CHIMIA, 2017
The present article offers an overview on the use of atomic force microscopy (AFM) to characterize the nanomechanical properties of polymers. AFM imaging reveals the conformations of polymer molecules at solid– liquid interfaces.
Milad Radiom, Christoph Weder, Katharina M. Fromm, Andreas F. M. Kilbinger, Plinio Maroni, Mathieu A. Ayer, Michela di Giannantonio, Phally Kong, Svilen Kozhuharov, Michal Borkovec   +9 more
doaj   +1 more source

Horizontal vibration response analysis of piles in liquefied soil under Winkler foundation model

Rock and Soil Mechanics, 2020
By considering the condition of vertical load, the soil after complete liquefaction is regarded as fluid, and the pile foundation is equivalent to the Euler-Bernoulli beam model.
XIONG Hui, YANG Feng
doaj   +1 more source

Quantification of the radiative forcing of contrails embedded in cirrus clouds

Nature Communications
Aviation leads to the emission of CO2 but also exerts non-CO2 effects on climate (Lee et al., 2021). The latter include line-shaped condensation trails (contrails) and contrail cirrus that are known to cause warming. However, contrails can also form in already existing cirrus clouds.
Seelig, Torsten, Wolf, Kevin, Bellouin, Nicolas, Tesche, Matthias   +3 more
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Structure design and optimization for a cutting force measurement tool with embedded nickel–chromium film sensor

Advances in Mechanical Engineering, 2018
The cutting force generated during the cutting process affects the quality of the workpieces and tool wear. Accurate real-time monitoring of cutting forces plays an important role in the study of cutting mechanism and machining quality improvement.
Xuerui Li, Wenge Wu, Yunping Cheng, Lijuan Liu   +3 more
doaj   +1 more source

Development of Field Excavator with Embedded Force Measurement [PDF]

Earth and Space 2012, 2012
A semi-intelligent excavation mechanism was developed for use with the NASA-built Centaur 2 rover prototype. The excavator features a continuously rotatable large bucket supported between two parallel arms, both of which share a single pivot axis near the excavator base attached to the rover.
K. Johnson, C. Creager, A. Izadnegahdar, S. Bauman, C. Gallo, P. Abel   +5 more
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Dowel Behavior of Rebars in Small Concrete Block for Sliding Slab Track on Railway Bridges

Advances in Materials Science and Engineering, 2018
In recent years, several studies have investigated the sliding slab track for railway bridges. In the design of sliding slab tracks, one of the most important considerations is to evaluate the shear capacity of the lateral supporting concrete blocks in ...
Seong-Cheol Lee, Sangmin Park, Jaeha Lee, Kyoung-Chan Lee   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source