Results 51 to 60 of about 2,735,473 (307)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Quantitative Nano-characterization of Polymers Using Atomic Force Microscopy

CHIMIA, 2017
The present article offers an overview on the use of atomic force microscopy (AFM) to characterize the nanomechanical properties of polymers. AFM imaging reveals the conformations of polymer molecules at solid– liquid interfaces.
Milad Radiom, Christoph Weder, Katharina M. Fromm, Andreas F. M. Kilbinger, Plinio Maroni, Mathieu A. Ayer, Michela di Giannantonio, Phally Kong, Svilen Kozhuharov, Michal Borkovec   +9 more
doaj   +1 more source

Horizontal vibration response analysis of piles in liquefied soil under Winkler foundation model

Rock and Soil Mechanics, 2020
By considering the condition of vertical load, the soil after complete liquefaction is regarded as fluid, and the pile foundation is equivalent to the Euler-Bernoulli beam model.
XIONG Hui, YANG Feng
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Structure design and optimization for a cutting force measurement tool with embedded nickel–chromium film sensor

Advances in Mechanical Engineering, 2018
The cutting force generated during the cutting process affects the quality of the workpieces and tool wear. Accurate real-time monitoring of cutting forces plays an important role in the study of cutting mechanism and machining quality improvement.
Xuerui Li, Wenge Wu, Yunping Cheng, Lijuan Liu   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Quantification of the radiative forcing of contrails embedded in cirrus clouds

Nature Communications
Aviation leads to the emission of CO2 but also exerts non-CO2 effects on climate (Lee et al., 2021). The latter include line-shaped condensation trails (contrails) and contrail cirrus that are known to cause warming. However, contrails can also form in already existing cirrus clouds.
Seelig, Torsten, Wolf, Kevin, Bellouin, Nicolas, Tesche, Matthias   +3 more
openaire   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dowel Behavior of Rebars in Small Concrete Block for Sliding Slab Track on Railway Bridges

Advances in Materials Science and Engineering, 2018
In recent years, several studies have investigated the sliding slab track for railway bridges. In the design of sliding slab tracks, one of the most important considerations is to evaluate the shear capacity of the lateral supporting concrete blocks in ...
Seong-Cheol Lee, Sangmin Park, Jaeha Lee, Kyoung-Chan Lee   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source