Results 91 to 100 of about 64,000 (305)

Quantum embedding theory in the screened Coulomb interaction: Combining configuration interaction with GW/BSE

, 2019
We present a quantum embedding theory called dynamical configuration interaction (DCI) that combines wave function and Green's function theories. DCI captures static correlation in a correlated subspace with configuration interaction and couples to high ...
Golze, Dorothea, Rinke, Patrick, Dvorak, Marc   +2 more
core   +1 more source

Theory and applications of evolvable embedded systems [PDF]

Proceedings. 11th IEEE International Conference and Workshop on the Engineering of Computer-Based Systems, 2004., 2004
We represent the first attempt to formulate a concept of the evolvable embedded system as a specialized kind of evolvable (hardware) systems. We define the class of evolvable embedded systems, describes a general framework for their modeling, introduces theoretical models, and reviews possible implementations and applications.
Lukás Sekanina, Vladimír Drábek
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Density Functional Theory Embedding for Correlated Wavefunctions [PDF]

, 2014
Methods that exploit the intrinsic locality of molecular interactions show significant promise in making tractable the electronic structure calculation of large-scale systems.
Goodpaster, Jason Daniel
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A High-Capacity 3D Steganography Algorithm With Adjustable Distortion

IEEE Access, 2017
In this paper, we devise a novel steganography algorithm that has a high capacity while still retaining the ability of adjusting the embedding distortion. A shifting strategy is explored to embed the secret data into a given 3-D model effectively.
Nannan Li, Jiangbei Hu, Riming Sun, Shengfa Wang, Zhongxuan Luo   +4 more
doaj   +1 more source

Embedding effective depression care: using theory for primary care organisational and systems change [PDF]

, 2010
Background: depression and related disorders represent a significant part of general practitioners (GPs) daily work. Implementing the evidence about what works for depression care into routine practice presents a challenge for researchers and service ...
May, Carl, Gunn, JM, Gunn, Jane M., Grant A Blashki, Caroline L Johnson, Palmer, Victoria J., Blashki, Grant, Victoria J Palmer, Kokanovic, R, Johnson Caroline L, Dowrick, Christopher, Blashki, Grant A., May, Carl R., Johnson, CL, Kelsey L Hegarty, Griffiths, Frances E, Hegarty, Kelsey, Potiriadis, M, Renata Kokanovic, May, CR, Herrman, Helen E., Frances E Griffiths, Gunn, Jane M, Dowrick, Christopher F, Gunn Jane M, Kokanovic Renata, Carl R May, Herrman, HE, Johnson, Caroline L., Hegarty Kelsey L, Palmer, VJ, Palmer Victoria J, Christopher F Dowrick, May Carl R, Herrman, Helen E, Johnson, Caroline L, Helen E Herrman, Potiriadis, Maria, Maria Potiriadis, Herrman Helen E, Gunn, Jane, Dowrick Christopher F, Dowrick, CF, Hegarty, Kelsey L., Hegarty, KL, Herrman, Helen, Hegarty, Kelsey L, Jane M Gunn, May, Carl R, Griffiths, FE, Blashki Grant A, Palmer, Victoria J, Potiriadis Maria, Dowrick, Christopher F., Blashki, Grant A, Blashki, GA, Griffiths Frances E, Griffiths, Frances, Griffiths, Frances E., Kokanovic, Renata   +59 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source