Results 1 to 10 of about 444,108 (317)

Embryo Genetics [PDF]

Genes, 2021
Advances in embryo and reproductive genetics have influenced clinical approaches to overcome infertility. Since the 1990s, many attempts have been made to decipher the genetic causes of infertility and to understand the role of chromosome aneuploidies in embryo potential.
Carmen Rubio, Carlos Simón
openaire   +2 more sources

The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway

Cells, 2022
Pituitary gonadotropins play a pivotal role in reproduction. Long noncoding RNAs (lncRNAs) have been identified as important regulators in the hypothalamic–pituitary–ovarian (HPO) axis associated with reproduction.
Zhen Wan, Hua Yang, Peiyong Chen, Zhibo Wang, Yu Cai, Xiaolei Yao, Feng Wang, Yanli Zhang   +7 more
doaj   +1 more source

Knockdown of KDM5B Leads to DNA Damage and Cell Cycle Arrest in Granulosa Cells via MTF1

Current Issues in Molecular Biology, 2023
KDM5B is essential for early embryo development, which is under the control of maternal factors in oocytes. Granulosa cells (GCs) play a critical role during oocyte mature. However, the role of KDM5B in GCs remains to be elucidated. In the current study,
Yingnan Yang, Yu Cai, Jinjing Guo, Keke Dai, Liang Liu, Zili Chen, Feng Wang, Mingtian Deng   +7 more
doaj   +1 more source

Cumulative live birth rates between GnRH-agonist long and GnRH-antagonist protocol in one ART cycle when all embryos transferred: real-word data of 18,853 women from China

Reproductive Biology and Endocrinology, 2021
Background A consensus has been reached on the preferred primary outcome of all infertility treatment trials, which is the cumulative live birth rate (CLBR).
Jingwei Yang, Xiaodong Zhang, Xiaoyan Ding, Yuting Wang, Guoning Huang, Hong Ye   +5 more
doaj   +1 more source

The transverse diameter of right common femoral vein by ultrasound in the supine position for predicting post-spinal hypotension during cesarean delivery

BMC Anesthesiology, 2021
Background Post-spinal anesthesia hypotension during cesarean delivery is caused by decreased systemic vascular resistance due to the blockage of the autonomic nerves, which is further worsened by inferior vena cava (IVC) compression by the gravid uterus.
Shi-Fa Yao, Yan-Hong Zhao, Jing Zheng, Jie-Yan Qian, Chen Zhang, Zifeng Xu, Tao Xu   +6 more
doaj   +1 more source

Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope

BMC Biology, 2023
Background Nme2ABE8e has been constructed and characterized as a compact, accurate adenine base editor with a less restrictive dinucleotide protospacer-adjacent motif (PAM: N4CC) but low editing efficiency at challenging loci in human cells.
Ding Zhao, Xun Gao, Jiale Zhou, Jinze Li, Yuqiang Qian, Di Wang, Wenchao Niu, Tao Zhang, Mingyang Hu, Haoyang Xiong, Liangxue Lai, Zhanjun Li   +11 more
doaj   +1 more source

A Study on Genes of Bayanbulak Sheep [PDF]

Asian-Australasian Journal of Animal Sciences, 2013
The average twin lambing rate of Bayanbulak sheep is 2% to 3%. However, a flock of sheep with a close genetic relationship and an average of 2 to 3 lambs per birth has been found recently.
Beiyao Zuo, Hongguang Qian, Ziyu Wang, Xu Wang, Noor Nisa, Aierdin Bayier, Shijia Ying, Xiaolong Hu, Changhai Gong, Zhiqin Guo, Feng Wang   +10 more
doaj   +1 more source

The Genetic Mutation of ANO5 in Rabbits Recapitulates Human Cardiomyopathy

Applied Sciences, 2020
The limb girdle muscular dystrophy type 2L (LGMD2L) is caused by mutations of the ANO5 gene in humans which encodes a 913 amino-acid integral membrane protein.
Tingting Sui, Hongwu Yao, Tao Zhang, Jinze Li, Liangxue Lai, Zhanjun Li   +5 more
doaj   +1 more source

Maternal Magnolol Supplementation during Pregnancy and Lactation Promotes Antioxidant Capacity, Improves Gut Health, and Alters Gut Microbiota and Metabolites of Weanling Piglets

Metabolites, 2023
Maternal nutrition exerts a profound effect on the postnatal performance of offspring, especially during the weaning period. The multifunctional bioactive component magnolol (MAG) has shown promise as a dietary supplement. This study aimed to explore the
Qiwen Fan, Encun Du, Fang Chen, Wenjing Tao, Na Zhao, Shaowen Huang, Wanzheng Guo, Jing Huang, Jintao Wei   +8 more
doaj   +1 more source

Global DNA methylation profiles of buffalo (Bubalus bubalis) preimplantation embryos produced by handmade cloning and in vitro fertilization

Scientific Reports, 2022
Somatic cell nuclear transfer technique (SCNT) has proved to be an outstanding method of multiplication of elite animals but accompanied with low efficiency and live birth rate of cloned animals. Epigenetic alterations of DNA has been one of the culprits
Shivani Malpotra, Pallavi Goel, Songyukta Shyam, Manoj Kumar Singh, Prabhat Palta   +4 more
doaj   +1 more source