Results 1 to 10 of about 929,316 (348)

Modeling mammalian gastrulation with embryonic stem cells [PDF]

arXiv, 2017
Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and molecular processes that shape the embryo.
Amita, Arnold, Azioune, Bauwens, Bedzhov, Ben-Haim, Bernardo, Blin, Bolouri, Chambers, Coucouvanis, Dunn, Engler, Etoc, Farin, Gjorevski, Green, Gurdon, Harrison, Heemskerk, Heemskerk, Horii, Lee, Lei, Li, Lippmann, Loh, Meinhardt, Meinhardt, Mendjan, Migeotte, Müller, Nakamura, Nallet-Staub, Nemashkalo, Nemashkalo, Nowotschin, Pagliuca, Peerani, Perea-Gomez, Przybyla, Qin, Ranga, Rosowski, Saka, Sasai, Schohl, Shao, Shao, Simunovic, Sorre, Sun, Tang, ten Berge, Teo, Tewary, Théry, Turing, Turner, Turner, van den Brink, Warmflash, Wilson, Xu, Yang, Yu   +65 more
arxiv   +3 more sources

Erythroid development in the mammalian embryo [PDF]

Blood Cells, Molecules, and Diseases, 2013
Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells
Johnathan L. Nieves, Andrei M. Vacaru, Margaret H. Baron   +2 more
openaire   +4 more sources

Principles of Self-Organization of the Mammalian Embryo

Cell, 2020
Early embryogenesis is a conserved and self-organized process. In the mammalian embryo, the potential for self-organization is manifested in its extraordinary developmental plasticity, allowing a correctly patterned embryo to arise despite experimental perturbation.
Magdalena Zernicka-Goetz, Magdalena Zernicka-Goetz, Meng Zhu, Meng Zhu   +3 more
openaire   +6 more sources

Insights into epigenetic patterns in mammalian early embryos

Protein & Cell, 2020
Mammalian fertilization begins with the fusion of two specialized gametes, followed by major epigenetic remodeling leading to the formation of a totipotent embryo. During the development of the pre-implantation embryo, precise reprogramming progress is a
Ruimin Xu, Chong Li, Xiaoyu Liu, Shaorong Gao   +3 more
doaj   +2 more sources

Instructions for Assembling the Early Mammalian Embryo [PDF]

Developmental Cell, 2018
The preimplantation mouse embryo is a simple self-contained system, making it an excellent model to discover how mammalian cells function in real time and in vivo. Work over the last decade has revealed some key morphogenetic mechanisms that drive early development, yielding rudimentary instructions for the generation of a mammalian embryo.
White, Melanie D., Zenker, Jennifer, Bissiere, Stephanie, Plachta, Nicolas   +3 more
openaire   +5 more sources

The signal that stimulates mammalian embryo development [PDF]

Frontiers in Cell and Developmental Biology
Embryo development is stimulated by calcium (Ca2+) signals that are generated in the egg cytoplasm by the fertilizing sperm. Eggs are formed via oogenesis.
Zoltan Machaty
doaj   +2 more sources

The Chicken Embryo: An Old but Promising Model for In Vivo Preclinical Research [PDF]

Biomedicines
The chicken embryo has emerged as a valuable model for preclinical studies due to its unique combination of accessibility, affordability, and relevance to human biology.
Annachiara Sarnella, Ylenia Ferrara, Cristina Terlizzi, Sandra Albanese, Serena Monti, Luca Licenziato, Marcello Mancini   +6 more
doaj   +2 more sources

Symmetry Breaking in the Mammalian Embryo

Annual Review of Cell and Developmental Biology, 2018
We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable us to explore progressive symmetry breaking during early mammalian development.
Takashi Hiiragi, Hui Ting Zhang
openaire   +4 more sources

Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo

Nature Communications, 2018
What breaks symmetry in early mammalian embryonic development has been much questioned. Here, Magdalena Zernicka-Goetz and colleagues propose that compartmentalized intracellular reactions generate micro-scale inhomogeneity, which is amplified in the ...
Qi Chen, Junchao Shi, Yi Tao, Magdalena Zernicka-Goetz   +3 more
doaj   +2 more sources

Controlled Dynamic Microfluidic Culture of Murine, Bovine, and Human Embryos Improves Development: Proof-of-Concept Studies [PDF]

Cells
Classical preimplantation embryo culture is performed in static fluid environments. Whether a dynamic fluid environment, like the fallopian tube, is beneficial for embryo development remains to be determined across mammalian species.
Jose Roberto Alegretti, Andre M. Da Rocha, Naiara C. Nogueira-de-Souza, Nobuhiro Kato, Bruna C. Barros, Eduardo L. A. Motta, Paulo C. Serafini, Shuichi Takayama, Gary D. Smith   +8 more
doaj   +2 more sources