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Symmetry Breaking in the Mammalian Embryo
Annual Review of Cell and Developmental Biology, 2018 We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable us to explore progressive symmetry breaking during early mammalian development.
Takashi Hiiragi
exaly +4 more sources
Instructions for Assembling the Early Mammalian Embryo [PDF]
Developmental Cell, 2018 The preimplantation mouse embryo is a simple self-contained system, making it an excellent model to discover how mammalian cells function in real time and in vivo. Work over the last decade has revealed some key morphogenetic mechanisms that drive early development, yielding rudimentary instructions for the generation of a mammalian embryo.
White, Melanie D. +3 more
openaire +6 more sources
Nature Communications, 2022 Mammalian embryogenesis relies on glycolysis and oxidative phosphorylation, but understanding of the dynamics of metabolic regulation in the postimplantation embryo in vivo remains elusive.
Anna Malkowska +3 more
doaj +2 more sources
Erythroid development in the mammalian embryo [PDF]
Blood Cells, Molecules, and Diseases, 2013 Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells
Margaret H, Baron +2 more
openaire +3 more sources
Insights into epigenetic patterns in mammalian early embryos
Protein & Cell, 2020 Mammalian fertilization begins with the fusion of two specialized gametes, followed by major epigenetic remodeling leading to the formation of a totipotent embryo. During the development of the pre-implantation embryo, precise reprogramming progress is a
Ruimin Xu +3 more
doaj +2 more sources
Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo
Nature Communications, 2018 What breaks symmetry in early mammalian embryonic development has been much questioned. Here, Magdalena Zernicka-Goetz and colleagues propose that compartmentalized intracellular reactions generate micro-scale inhomogeneity, which is amplified in the ...
Qi Chen +3 more
doaj +2 more sources
Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development
Nature Communications, 2023 Although more studies are demonstrating that a father’s environment can influence child health and disease, the molecular mechanisms underlying non-genetic inheritance remain unclear.
A. Lismer, S. Kimmins
semanticscholar +1 more source
Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices.
Cell, 2023 Mammalian oocytes are filled with poorly understood structures called cytoplasmic lattices. First discovered in the 1960s and speculated to correspond to mammalian yolk, ribosomal arrays, or intermediate filaments, their function has remained enigmatic ...
I. Jentoft +18 more
semanticscholar +1 more source
An in vitro stem cell model of human epiblast and yolk sac interaction
eLife, 2021 Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay +10 more
doaj +1 more source
Reactive oxygen species in the mammalian pre-implantation embryo.
Reproduction, 2022 Reactive Oxygen Species (ROS) occur naturally in pre-implantation embryos as a by-product of ATP generation through oxidative phosphorylation and enzymes such as NADPH oxidase and xanthine oxidase.
Joshua C Deluao +5 more
semanticscholar +1 more source