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Transgene-free mouse embryo models from chemical reprogramming reach early organogenesis [PDF]

Cell Regeneration
Embryo models derived from pluripotent stem cells (PSCs) have become powerful tools for dissecting mammalian embryonic development and advancing regenerative medicine.
Xiu Yu, Jichang Wang
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The signal that stimulates mammalian embryo development

Frontiers in Cell and Developmental Biology
Embryo development is stimulated by calcium (Ca2+) signals that are generated in the egg cytoplasm by the fertilizing sperm. Eggs are formed via oogenesis.
Zoltan Machaty
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An in vitro stem cell model of human epiblast and yolk sac interaction

eLife, 2021
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz   +10 more
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A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

Nature Communications, 2021
Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development
Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz   +18 more
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Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Cell Reports, 2021
Summary: At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the
Matteo Amitaba Molè, Antonia Weberling, Reinhard Fässler, Alison Campbell, Simon Fishel, Magdalena Zernicka-Goetz   +5 more
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Stain-free detection of embryo polarization using deep learning

Scientific Reports, 2022
Polarization of the mammalian embryo at the right developmental time is critical for its development to term and would be valuable in assessing the potential of human embryos.
Cheng Shen, Adiyant Lamba, Meng Zhu, Ray Zhang, Magdalena Zernicka-Goetz, Changhuei Yang   +5 more
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IVEN: A quantitative tool to describe 3D cell position and neighbourhood reveals architectural changes in FGF4-treated preimplantation embryos.

PLoS Biology, 2021
Architectural changes at the cellular and organism level are integral and necessary to successful development and growth. During mammalian preimplantation development, cells reduce in size and the architecture of the embryo changes significantly.
Jessica E Forsyth, Ali H Al-Anbaki, Roberto de la Fuente, Nikkinder Modare, Diego Perez-Cortes, Isabel Rivera, Rowena Seaton Kelly, Simon Cotter, Berenika Plusa   +8 more
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Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development

Frontiers in Cell and Developmental Biology, 2021
From fertilization to onset of gastrulation, a mammalian embryo goes through several rounds of cellular morphogenesis resembling phenomena of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), collectively referred to as
Galym Ismagulov, Sofiane Hamidi, Guojun Sheng   +2 more
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Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β

Frontiers in Immunology, 2022
Mammalian blastocyst hatching is an essential prerequisite for successful embryo implantation. As the rate-limiting step of current assisted reproductive technology, understanding the key factors regulating blastocyst hatching would be significantly ...
Guangping Yang, Jianhua Chen, Yanni He, Hui Luo, Hongxia Yuan, Liangliang Chen, Lingli Huang, Fei Mao, Saifei Hu, Yun Qian, Congxiu Miao, Ruizhi Feng, Ruizhi Feng   +12 more
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A hexa-species transcriptome atlas of mammalian embryogenesis delineates metabolic regulation across three different implantation modes

Nature Communications, 2022
Mammalian embryogenesis relies on glycolysis and oxidative phosphorylation, but understanding of the dynamics of metabolic regulation in the postimplantation embryo in vivo remains elusive.
Anna Malkowska, Christopher Penfold, Sophie Bergmann, Thorsten E. Boroviak   +3 more
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