Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
Nature Communications, 2019 How the shape of the pre-implantation murine embryo changes dramatically upon implantation is unclear. Here, the authors use live imaging with a cdx2-GFP reporter line in combination with loss of function experiments to demonstrate that FGF signalling ...
Neophytos Christodoulou +5 more
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Molecular recording of mammalian embryogenesis. [PDF]
, 2019 Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt +13 more
core +2 more sources
Editing DNA Methylation in Mammalian Embryos [PDF]
International Journal of Molecular Sciences, 2020 DNA methylation in mammals is essential for numerous biological functions, such as ensuring chromosomal stability, genomic imprinting, and X-chromosome inactivation through transcriptional regulation. Gene knockout of DNA methyltransferases and demethylation enzymes has made significant contributions to analyzing the functions of DNA methylation in ...
Taiga Yamazaki +4 more
openaire +2 more sources
Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans. [PDF]
, 2014 To better understand the role of radial glial (RG) cells in the evolution of the mammalian cerebral cortex, we investigated the role of RG cells in the dorsal cortex and dorsal ventricular ridge of the turtle, Trachemys scripta elegans.
Clinton, Brian K +4 more
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Haemogenic endocardium contributes to transient definitive haematopoiesis. [PDF]
, 2013 Haematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a close relationship among cardiac, endocardial and haematopoietic ...
Arshi, Armin +14 more
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Insights into epigenetic patterns in mammalian early embryos
Protein & Cell, 2020 Mammalian fertilization begins with the fusion of two specialized gametes, followed by major epigenetic remodeling leading to the formation of a totipotent embryo. During the development of the pre-implantation embryo, precise reprogramming progress is a
Ruimin Xu +3 more
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Complications Associated with Uterine Artery Embolisation for Fibroids
Obstetrics and Gynecology International, 2012 Uterine artery embolisation (UAE) is a relative newcomer to the mainstream treatment modalities available for fibroid-related problems. The efficacy of UAE is indisputable and has been shown to be comparable to hysterectomy in the short term in large ...
Maria Memtsa, Hayden Homer
doaj +1 more source
Protocadherin-1 is expressed in the notochord of mouse embryo but is dispensable for its formation
Biochemistry and Biophysics Reports, 2021 Notochord is an embryonic midline structure that serves as mechanical support for axis elongation and the signaling center for the surrounding tissues.
Kanako Fukunaga +4 more
doaj +1 more source
The meganuclease I-SceI containing nuclear localization signal (NLS-I-SceI) efficiently mediated mammalian germline transgenesis via embryo cytoplasmic microinjection. [PDF]
PLoS ONE, 2014 The meganuclease I-SceI has been effectively used to facilitate transgenesis in fish eggs for nearly a decade. I-SceI-mediated transgenesis is simply via embryo cytoplasmic microinjection and only involves plasmid vectors containing I-SceI recognition ...
Yong Wang +7 more
doaj +1 more source
The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature [PDF]
, 2010 In vertebrates, body musculature originates from somites, whereas head muscles originate from the cranial mesoderm. Neck muscles are located in the transition between these regions.
Christ, B. +9 more
core +1 more source