Results 1 to 10 of about 199,433 (310)

Modeling mammalian gastrulation with embryonic stem cells [PDF]

arXiv, 2017
Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and ...
Amita, Arnold, Azioune, Bauwens, Bedzhov, Ben-Haim, Bernardo, Blin, Bolouri, Chambers, Coucouvanis, Dunn, Engler, Etoc, Farin, Gjorevski, Green, Gurdon, Harrison, Heemskerk, Heemskerk, Horii, Lee, Lei, Li, Lippmann, Loh, Meinhardt, Meinhardt, Mendjan, Migeotte, Müller, Nakamura, Nallet-Staub, Nemashkalo, Nemashkalo, Nowotschin, Pagliuca, Peerani, Perea-Gomez, Przybyla, Qin, Ranga, Rosowski, Saka, Sasai, Schohl, Shao, Shao, Simunovic, Sorre, Sun, Tang, ten Berge, Teo, Tewary, Théry, Turing, Turner, Turner, van den Brink, Warmflash, Wilson, Xu, Yang, Yu   +65 more
core   +2 more sources

The Chicken Embryo: An Old but Promising Model for In Vivo Preclinical Research [PDF]

Biomedicines
The chicken embryo has emerged as a valuable model for preclinical studies due to its unique combination of accessibility, affordability, and relevance to human biology.
Annachiara Sarnella, Ylenia Ferrara, Cristina Terlizzi, Sandra Albanese, Serena Monti, Luca Licenziato, Marcello Mancini   +6 more
doaj   +2 more sources

Controlled Dynamic Microfluidic Culture of Murine, Bovine, and Human Embryos Improves Development: Proof-of-Concept Studies [PDF]

Cells
Classical preimplantation embryo culture is performed in static fluid environments. Whether a dynamic fluid environment, like the fallopian tube, is beneficial for embryo development remains to be determined across mammalian species.
Jose Roberto Alegretti, Andre M. Da Rocha, Naiara C. Nogueira-de-Souza, Nobuhiro Kato, Bruna C. Barros, Eduardo L. A. Motta, Paulo C. Serafini, Shuichi Takayama, Gary D. Smith   +8 more
doaj   +2 more sources

The signal that stimulates mammalian embryo development

Frontiers in Cell and Developmental Biology
Embryo development is stimulated by calcium (Ca2+) signals that are generated in the egg cytoplasm by the fertilizing sperm. Eggs are formed via oogenesis.
Zoltan Machaty
doaj   +3 more sources

Effects of gravity, microgravity or microgravity simulation on early mouse embryogenesis: A review of the first two space embryo studies [PDF]

Mechanobiology in Medicine
Many simulated micro-gravity (micro-G) experiments on earth suggest that micro-G conditions are not compatible with early mammalian embryo development.
Douglas M. Ruden, Daniel A. Rappolee
doaj   +2 more sources

An in vitro stem cell model of human epiblast and yolk sac interaction

eLife, 2021
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz   +10 more
doaj   +1 more source

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

Nature Communications, 2021
Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development
Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz   +18 more
doaj   +1 more source

Stain-free detection of embryo polarization using deep learning

Scientific Reports, 2022
Polarization of the mammalian embryo at the right developmental time is critical for its development to term and would be valuable in assessing the potential of human embryos.
Cheng Shen, Adiyant Lamba, Meng Zhu, Ray Zhang, Magdalena Zernicka-Goetz, Changhuei Yang   +5 more
doaj   +1 more source

Epithelial-Mesenchymal Transition Drives Three-Dimensional Morphogenesis in Mammalian Early Development

Frontiers in Cell and Developmental Biology, 2021
From fertilization to onset of gastrulation, a mammalian embryo goes through several rounds of cellular morphogenesis resembling phenomena of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), collectively referred to as
Galym Ismagulov, Sofiane Hamidi, Guojun Sheng   +2 more
doaj   +1 more source

Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β

Frontiers in Immunology, 2022
Mammalian blastocyst hatching is an essential prerequisite for successful embryo implantation. As the rate-limiting step of current assisted reproductive technology, understanding the key factors regulating blastocyst hatching would be significantly ...
Guangping Yang, Jianhua Chen, Yanni He, Hui Luo, Hongxia Yuan, Liangliang Chen, Lingli Huang, Fei Mao, Saifei Hu, Yun Qian, Congxiu Miao, Ruizhi Feng, Ruizhi Feng   +12 more
doaj   +1 more source