Results 11 to 20 of about 536,166 (300)
Instructions for Assembling the Early Mammalian Embryo [PDF]
Developmental Cell, 2018 The preimplantation mouse embryo is a simple self-contained system, making it an excellent model to discover how mammalian cells function in real time and in vivo. Work over the last decade has revealed some key morphogenetic mechanisms that drive early development, yielding rudimentary instructions for the generation of a mammalian embryo.
White, Melanie D. +3 more
openaire +6 more sources
Blood flow and the mammalian embryo [PDF]
, 2005 Hemodynamics, or blood fluid dynamics, is of great importance in vascular biology and its role is well recognized in events ranging from atherosclerosis to wound healing. The importance of hemodynamics during embryonic development, however, is less clear.
Jones, Elizabeth Anne Vincent
openaire +3 more sources
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo [PDF]
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +2 more sources
Chromatin remodeling in mammalian embryos [PDF]
Reproduction, 2018 Abstract The mammalian embryo undergoes a dramatic amount of epigenetic remodeling during the first week of development. In this review, we discuss several epigenetic changes that happen over the course of cleavage development, focusing on covalent marks (e.g., histone methylation and acetylation) and non-covalent remodeling ...
Birgit, Cabot, Ryan A, Cabot
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Erythroid development in the mammalian embryo [PDF]
Blood Cells, Molecules, and Diseases, 2013 Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells
Margaret H, Baron +2 more
openaire +2 more sources
Application of a Microfluidic Chip with Mechanical Stimuli for Culturing Mouse Embryos in vitro [PDF]
International Journal Bioautomation, 2018 In order to solve some problems of lower blastocyst rate of early embryos in vitro and poor quality of blastocyst, application of a microfluidic chip with mechanical stimuli (MS) to imitate microenvironment of fallopian tube, to investigate the effect of
Jingchun Li +5 more
doaj +1 more source
Biophysical models of early mammalian embryogenesis
Stem Cell Reports, 2023 Summary: Embryo development is a critical and fascinating stage in the life cycle of many organisms. Despite decades of research, the earliest stages of mammalian embryogenesis are still poorly understood, caused by a scarcity of high-resolution spatial ...
Alaina Cockerell +6 more
doaj +1 more source
Developmental potential of aneuploid human embryos cultured beyond implantation
Nature Communications, 2020 Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 ...
Marta N. Shahbazi +11 more
doaj +1 more source
Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo [PDF]
, 2004 We have investigated the contribution of the tight junction (TJ) transmembrane protein junction-adhesion-molecule 1 (JAM-1) to trophectoderm epithelial differentiation in the mouse embryo.
Fay C. Thomas +11 more
core +1 more source
They Can't Have My Embryo: The Ethics of Conditional Embryo Donation [PDF]
, 2013 There are substantial numbers of frozen embryos in storage that will not be used by those who produced them for their own fertility treatment. One option for such embryos is to donate them to others to use in their fertility treatment.
Eric Blyth +4 more
core +1 more source