Results 161 to 170 of about 208,388 (190)

Experimental genetics of the mammalian embryo

Journal of Cellular Physiology, 1982
Recent progress in experimental mouse embryology has provided new approaches to the genetic manipulation of the mammalian embryo. The production of uniparental embryos enables one to compare maternal and paternal gene activity during development, to study the biological consequences of homozygosity of mutant genes, and to further elucidate the unsolved
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Apoptosis in Mammalian Embryos

2002
The preimplantation development of eutherian mammals is remarkably similar, spanning cleavage of the fertilized ovum; compaction and morula formation; and finally cavitation, with the formation of a blastocyst. Blastocyst formation marks the differentiation of the epithelial trophectoderm (TE), which is specialized for implantation, and the ...
S Spanos, Kate Hardy
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Cryopreservation of Mammalian Embryos

1988
Early investigations of the effects of cooling and rewarming cells employed both spermatozoa and ova as experimental material. Spermatozoa were selected because of the ease of collection, inherent motility, and small size. Oocytes were employed mainly for their large size which allowed direct morphological observations.
Patrick Quinn, Frank B. Kuzan
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DNA repair in mammalian embryos

Mutation Research/Reviews in Mutation Research, 2007
Mammalian cells have developed complex mechanisms to identify DNA damage and activate the required response to maintain genome integrity. Those mechanisms include DNA damage detection, DNA repair, cell cycle arrest and apoptosis which operate together to protect the conceptus from DNA damage originating either in parental gametes or in the embryo's ...
S. Jaroudi, Sioban SenGupta
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The function of glypicans in the mammalian embryo

American Journal of Physiology-Cell Physiology, 2022
Glypicans are proteoglycans that are bound to the outer surface of the plasma membrane by a glycosylphosphatidylinositol anchor. The mammalian genome contains six members of the glypican family ( GPC1 to GPC6). Although the degree of sequence homology within the family is rather low, the three-dimensional structure of these proteoglycans is highly ...
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The Regulative Nature of Mammalian Embryos

2018
The striking developmental plasticity of early mammalian embryos has been known since the classical experiments performed in the 1950s and 1960s. There are many lines of evidence that the mammalian embryo is able to continue normal development even when exposed to severe experimental manipulations of the number and position of cells within the embryo ...
Anna Kasperczuk, Aneta Suwińska, Katarzyna Klimczewska   +2 more
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Symmetry Breaking in the Mammalian Embryo

Annual Review of Cell and Developmental Biology, 2018
We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable us to explore progressive symmetry breaking during early mammalian development.
Takashi Hiiragi, Hui Ting Zhang
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Encapsulation of Mammalian Embryos

1999
Encapsulation of mammalian preimplantation embryos has its origins in the work of Willadsen in the late 1970s and in the need to develop an artificial zona pellucida for denuded sheep, horse, and cattle embryos used in the production of monozygotic twins for the livestock industry.
Glen K. Adaniya, Richard G. Rawlins
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Nuclear Transfer in Mammalian Embryos

1990
Publisher Summary This chapter discusses the nuclear transfer in mammalian embryos. Transfer of nuclei from one cell to another provides a powerful method to study the interactions of the cytoplasm of one cell with the nuclei of another. Nuclei from various differentiated states can be transferred to nondifferentiated cytoplasm and the effect on the ...
Neal L. First, Randall S. Prather
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Erythropoiesis in the mammalian embryo

Experimental Hematology
Red blood cells (RBCs) comprise a critical component of the cardiovascular network, which constitutes the first functional organ system of the developing mammalian embryo. Examination of circulating blood cells in mammalian embryos revealed two distinct types of erythroid cells: large, nucleated "primitive" erythroblasts followed by smaller, enucleated
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