Results 161 to 170 of about 936,605 (354)

PreImplantation Factor (PIF) correlates with early mammalian embryo development-bovine and murine models

Reproductive Biology and Endocrinology, 2011
BackgroundPreImplantation Factor (PIF), a novel peptide secreted by viable embryos is essential for pregnancy: PIF modulates local immunity, promotes decidual pro-adhesion molecules and enhances trophoblast invasion.
Christopher W. Stamatkin, R. Roussev, M. Stout, V. Absalón-Medina, S. Ramu, C. Goodman, C. Coulam, R. Gilbert, R. Godke, E. Barnea   +9 more
semanticscholar   +1 more source

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source

A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo.

Blood, 2011
A transient erythromyeloid wave of definitive hematopoietic progenitors (erythroid/myeloid progenitors [EMPs]) emerges in the yolk sac beginning at embryonic day 8.25 (E8.25) and colonizes the liver by E10.5, before adult-repopulating hematopoietic stem ...
K. McGrath, Jenna M. Frame, George Fromm, A. Koniski, P. Kingsley, J. Little, M. Bulger, J. Palis   +7 more
semanticscholar   +1 more source

Genomic Insights into Post‐Domestication Expansion and Selection of Body Size in Ponies

Advanced Science, EarlyView.
The authors’ research delves into the history of ponies by assembling a pony genome and integrating horse genomes. This unveils genetic connections between Asian and European pony breeds. Cis‐regulatory elements of key genes impacting body size are also identified.
Xingzheng Li, Zihao Wang, Min Zhu, Binhu Wang, Shaohua Teng, Jing Yan, Haoyu Wang, Pengxiang Yuan, Shuwei Cao, Xiaolu Qu, Zhen Wang, Kai Zhan, Md. Panir Choudhury, Xintong Yang, Qi Bao, Sang He, Lei Liu, Pengju Zhao, Jicai Jiang, Hai Xiang, Lingzhao Fang, Zhonglin Tang, Yuying Liao, Guoqiang Yi   +23 more
wiley   +1 more source

Formation and Function of Mammalian Epithelia: Roles for Mechanosensitive PIEZO1 Ion Channels

Frontiers in Cell and Developmental Biology, 2019
Mechanical forces play important roles in shaping mammalian development. In the embryo, cells experience force both during the formation of the mammalian body plan and in the ensuing phase of organogenesis.
Teneale A. Stewart, Teneale A. Stewart, Felicity M. Davis, Felicity M. Davis   +3 more
doaj   +1 more source

Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids

Development, 2017
The establishment of the anteroposterior (AP) axis is a crucial step during animal embryo development. In mammals, genetic studies have shown that this process relies on signals spatiotemporally deployed in the extra-embryonic tissues that locate the ...
D. A. Turner, M. Girgin, L. Alonso-Crisóstomo, V. Trivedi, P. Baillie-Johnson, C. Glodowski, P. Hayward, J. Collignon, C. Gustavsen, P. Serup, B. Steventon, Matthias P. Lutolf, A. M. Arias   +12 more
semanticscholar   +1 more source

Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis

Advanced Science, EarlyView.
Squamocin disrupts mitochondrial respiratory Complex I function, reduces ATP production, and impairs HSP90α function, provoking endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in multiple cancer tumor models cell lines and in vivo tumor models.
Yin Zhu, Yurui Liu, Xiangtao Wang, Zhifeng Chen, Baojian Chen, Bingxin Hu, Tiane Tang, Haoran Cheng, Xinglong Liu, Yunshan Ning   +9 more
wiley   +1 more source

A $4,000 Workstation for Mammalian Genome Assembly with Long Reads [PDF]

arXiv, 2017
Long-read sequencing has enabled the de novo assembly of several mammalian genomes, but with high cost in computing. Here, we demonstrated de novo assembly of mammalian genome using long reads in an efficient and inexpensive workstation.
arxiv  

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast

Development, 2017
Single-cell profiling techniques create opportunities to delineate cell fate progression in mammalian development. Recent studies have provided transcriptome data from human pre-implantation embryos, in total comprising nearly 2000 individual cells ...
G. Stirparo, Thorsten E. Boroviak, G. Guo, J. Nichols, Austin G Smith, Paul Bertone   +5 more
semanticscholar   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source