Results 191 to 200 of about 936,605 (354)
IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex
Advanced Science, EarlyView.This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv +6 more
wiley +1 more source
Advanced Science, EarlyView.This work maps 3′‐UTR APA across mouse fetal development and tissues, identifying conserved sequence determinants that influence pAS choice. In fetal brain tissues, complex APA dynamics during development are potentially regulated by RBPs like Rbm38, which restrict distal pAS usage.
Qin Wang, Xin Chen, Xiao‐Ou Zhang
wiley +1 more source
Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering
Aggregate, EarlyView.Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang +3 more
wiley +1 more source
The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup [PDF]
, 2006 Background: Polarised gene expression is thought to lead to the graded distribution of signaling molecules providing a patterning mechanism across the embryonic eye.
Behesti, H, Holt, JKL, Sowden, JC
core
Immunocytochemistry in Early Mammalian Embryos
, 2012 The preimplantation period of mammalian development hosts very important cellular and molecular events. This period starts with the fertilization of oocyte by sperm, a process that reprograms the highly differentiated nuclei of these germ cells, and leads to the generation of a totipotent one-cell embryo.
openaire +4 more sources
S22 Micromanipulation of mammalian embryos
The Journal of Toxicological Sciences, 1988 Micromanipulation of embryos provide a new and valuable biological tool for animal agriculture and medical fields. Current techniques for embryo manipulation are in practice but some of techniques is still way off for application. The present status in new biotechnology appling to animal science and medicine is reviewed and its future is also discussed.
openaire +3 more sources
Animal Models and Experimental Medicine, EarlyView.In this study, we conducted measurements to determine the content of dianthrones in Polygoni Multiflori Radix (PMR) and Polygoni Multiflori Radix Praeparata (PMRP) samples from different stages of processing. Furthermore, we evaluated their hepatotoxicity using the human hepatocyte cell line L02 and Zebrafish embryos.
Wan‐Fang Li +6 more
wiley +1 more source
Animal models of human herpesvirus infection
Animal Models and Experimental Medicine, EarlyView.Human herpesvirus can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing.
Ziqing Jia +3 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The exon 16 of the mouse Apc gene was targeted with CRISPR/Cas9 system and a novel Apc knockout mouse model was generated by creating a frameshift mutation at codon 750 (ApcΔ750). The polyp number, polyp distribution and the overall survival of mice carrying the ApcΔ750 allele significantly differs between the F8‐FVB‐ApcΔ750 and F4‐B6;FVB‐ApcΔ750 mouse
Sarp Uzun +7 more
wiley +1 more source
Angewandte Chemie International Edition, Accepted Article.Chemical probes that control the function of complex RNA molecules offer unique opportunities to interrogate biological systems. In this study, we demonstrate that a small molecule ligand selectively recognizes and undergoes traceless, reversible photocrosslinking to PreQ1 RNA aptamers.
Shaifaly Parmar +5 more
wiley +1 more source