Primitive erythropoiesis in the mammalian embryo
The International Journal of Developmental Biology, 2010 Erythropoiesis in adult mammals is characterized by the progressive maturation of hematopoietic stem cells to lineage-specific progenitors, to morphologically identifiable precursors which enucleate to form mature erythrocytes. In contrast, primitive erythropoiesis is characterized by the appearance within the yolk sac of a transient, lineage ...
Jeffrey Malik +3 more
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Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. [PDF]
, 2016 The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration.
CHISHOLM, Andrew, Tang, Ngang
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The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature [PDF]
, 2010 In vertebrates, body musculature originates from somites, whereas head muscles originate from the cranial mesoderm. Neck muscles are located in the transition between these regions.
Christ, B. +9 more
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Instructions for Assembling the Early Mammalian Embryo [PDF]
Developmental Cell, 2018 The preimplantation mouse embryo is a simple self-contained system, making it an excellent model to discover how mammalian cells function in real time and in vivo. Work over the last decade has revealed some key morphogenetic mechanisms that drive early development, yielding rudimentary instructions for the generation of a mammalian embryo.
White, Melanie D. +3 more
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Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]
, 2010 Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
Achi +42 more
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Methylation Status of Imprinted Genes and Repetitive Elements in Sperm DNA from Infertile Males [PDF]
, 2011 Stochastic, environmentally and/or genetically induced disturbances in the genome-wide epigenetic reprogramming processes during male germ-cell development may contribute to male infertility.
El Hajj, N. +7 more
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Building Principles for Constructing a Mammalian Blastocyst Embryo
Biology, 2018 The self-organisation of a fertilised egg to form a blastocyst structure, which consists of three distinct cell lineages (trophoblast, epiblast and hypoblast) arranged around an off-centre cavity, is unique to mammals.
Peter L. Pfeffer
doaj +1 more source
Principles of Self-Organization of the Mammalian Embryo
Cell, 2020 Early embryogenesis is a conserved and self-organized process. In the mammalian embryo, the potential for self-organization is manifested in its extraordinary developmental plasticity, allowing a correctly patterned embryo to arise despite experimental perturbation.
Magdalena Zernicka-Goetz +3 more
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A 3D mechanical model of the early mammalian embryo [PDF]
, 2009 The early development of the mammalian embryo leads to the formation of a structure composed by an outer layer of polarized cells surrounding an inner mass of nonpolarized cells.
Dard, Nicolas +5 more
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TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]
, 2015 The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset.
Bhalla, Needhi +3 more
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