Results 41 to 50 of about 10,658 (118)

Temporal Loss of Genome‐Wide and Immunogenetic Diversity in a Near‐Extinct Parrot

Molecular Ecology, Volume 34, Issue 9, May 2025.
ABSTRACT Loss of genetic diversity threatens a species' adaptive potential and long‐term resilience. Predicted to be extinct by 2038, the orange‐bellied parrot (Neophema chrysogaster) is a critically endangered migratory bird threatened by numerous viral, bacterial and fungal diseases.
Luke W. Silver, Katherine A. Farquharson, Emma Peel, M. Thomas P. Gilbert, Katherine Belov, Hernán E. Morales, Carolyn J. Hogg   +6 more
wiley   +1 more source

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. [PDF]

, 2018
We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. Here, we used an shRNA screening approach to mimic miRNA activity on experimentally verified miR-196b targets
Aronow, Bruce J., Doench, John G., Grimes, H. Leighton, Lal, Ashish, Lieberman, Judy, McGlinn, Edwina, Meyer, Sara E., Morris, Patrick J., Muench, David E., Newkold, Tess J., O\u27Brien, Eric, Orr, Emily, Perentesis, John P., Rogers, Andrew M., Salomonis, Nathan, Thomas, Craig J.   +15 more
core   +2 more sources

Pattern generating role for motoneurons in a rythmically active neuronal network [PDF]

, 1998
The role of motoneurons in central motor pattern generation was investigated in the feeding system of the pond snail Lymnaea stagnalis, an important invertebrate model of behavioral rhythm generation.
Benjamin, Paul R, Kemenes, György, Staras, Kevin   +2 more
core   +2 more sources

On the Fila Olfactoria and the Cribriform Region of the Crocodylia

Journal of Morphology, Volume 286, Issue 2, February 2025.
The fila olfactoria of Alligator mississippiensis courses through a perforated pad of dense connective tissue to reach the olfactory bulb. The perforations are formed by perineural spaces, which produce continuity between the CSF and the olfactory submucosa.
Matthew Dille, Michael Cramberg, Hadyn DeLeeuw, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Xenopus as a model system for studying pigmentation and pigmentary disorders

Pigment Cell &Melanoma Research, Volume 38, Issue 1, January 2025.
The amphibian Xenopus is a vertebrate animal model ideal for studying pigmentation changes in vivo due to its numerous advantages. These include shared evolutionary ancestry with mammals, high offspring production, cost‐effective housing, the ability to perform live cell imaging, and well‐developed genetic techniques, including gain‐ and loss‐of ...
Joudi El Mir, Ali Nasrallah, Nadine Thézé, Muriel Cario, Hussein Fayyad‐Kazan, Pierre Thiébaud, Hamid‐Reza Rezvani   +6 more
wiley   +1 more source

Biting into the Genome to Phenome Map: Developmental Genetic Modularity of Cichlid Fish Dentitions [PDF]

, 2016
Within vertebrates, teleost fishes provide a rich evolutionary context for studying the mechanisms of dental divergence because of the numerous axes along which their teeth have diverged phenotypically and presumably developmentally.
Fraser, G.J., Hulsey, C.D., Meyer, A.
core   +1 more source

Animal models in neuroscience with alternative approaches: Evolutionary, biomedical, and ethical perspectives

Animal Models and Experimental Medicine, Volume 7, Issue 6, Page 868-880, December 2024.
Animal models have played a key role in neuroscience research for years. Nevertheless, their usage brings up ethical and transability issues concerning humans. In the recent years, alternative approaches have been developed, containing a potential for replacement and reduction of animal experimenting, associated with more relatable results. This review
Sabina Neziri, Ahmet Efe Köseoğlu, Gülsüm Deniz Köseoğlu, Buminhan Özgültekin, Nehir Özdemir Özgentürk   +4 more
wiley   +1 more source

Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells [PDF]

, 2002
In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for sensory and autonomic neurogenesis, respectively.
Anderson, David J., Dormand, Emma, Greenwood, Amy, Lo, Liching   +3 more
core  

Workgroup Report: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies [PDF]

, 2007
This is the report of the first workshop on Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies, held in Ispra, Italy, on 19–21 April 2005.
Abby Li, Alan M Goldberg, Anna Bal-Price, Coecke S, Cooper HM, David Owen, Ellen Silbergeld, Eskes C, Florianne Monnet-Tschudi, Gemma Calamandrei, Genschow E, Heck N, Holger Knaut, Kevin Crofton, Lars Hareng, Leonora Buzanska, Miriam Jacobs, Monnet-Tschudi F, Monnet-Tschudi F, Pahlman S, Pamela Lein, Paul Honegger, Prieto P, Reichel A, Sachana M, Sandra Allen, Sandra Coecke, Steffen Schneider, Thomas Hartung, Tomas Trnovec, Torsten Reum, Turka LA, van den Heuvel S, van Pelt J, Veronesi B, Volovitch M, William Mundy   +36 more
core   +3 more sources

The S2 Pocket Governs the Genus‐Specific Substrate Selectivity of Coronavirus 3C‐Like Protease

Advanced Science, Volume 11, Issue 44, November 26, 2024.
This study reveals the critical role of the S2 pocket in coronavirus 3C‐like protease (CoV 3CLpro) for substrate selectivity and its variability across CoV genera. Analysis of ancestral and modern 3CLpros sheds light on evolutionary processes and their effect on the efficacy of PF‐07321332.
Junwei Zhou, Peng Sun, Zhixiang Yang, Taiquan Wang, Jiahui Guo, Runhui Qiu, Zhuang Li, Dengguo Wei, Jinshui Zheng, Guiqing Peng, Liurong Fang, Shaobo Xiao   +11 more
wiley   +1 more source