Results 11 to 20 of about 444,108 (317)
Revista Científica, 2023 Buffalo cloning is a powerful assisted reproductive tool for multiplying elite buffalo germplasm. However, the live off-spring production efficiency is low due to aberrant epigenetic reprogramming.
Sonal Gupta +6 more
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Developmental Biology, 2000 A lesson learned from modern developmental biology is the striking degree of conservation of strategies and molecules used to program developmental events in species as diverse as insects, birds, amphibians, and mammals. Nonetheless, mammals retain distinctions with regard to the strategies used to protect and nourish their offspring during development,
Carson, Daniel D. +6 more
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Proceedings of the National Academy of Sciences, 2011 Generation of transgenic mice by pronuclear DNA injection into fertilized eggs has been well-established for over 30 y (1). However, it remains a rather crude approach: injected sequences randomly insert as concatamers, they can be mutagenic, and they have variable expression depending on the site of integration, a phenomenon called position effects ...
Janet Rossant +2 more
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Clinical Medicine Insights: Oncology, 2022 Background: Endometrial cancer (EC) is a common gynecological malignancy, and the prognosis of advanced EC is unsatisfactory. The deregulated expression of RNA-binding proteins (RBPs) is closely associated with the occurrence and development of cancer ...
Shuang Yuan, Xiao Sun, Lihua Wang
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Molecular Therapy: Methods & Clinical Development, 2016 Our ability to decipher gene sequences has increased enormously with the advent of modern sequencing tools, but the ability to divulge functions of new genes have not increased correspondingly.
Abul Usmani +8 more
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CRISPR/Cas9-mediated mutation of tyrosinase (Tyr) 3′ UTR induce graying in rabbit
Scientific Reports, 2017 The 3′ untranslated regions (UTRs), located at the end of mRNA molecules, are believed to play a role in RNA replication and/or protein translation. Mutations in the tyrosinase (Tyr) gene are known to cause recessive albinism in humans and other species.
Yuning Song +10 more
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Scientific Reports, 2017 Spermatogenesis can be affected by nutrition, which operates through normal physiological processes by changing the testicular mass and hormone levels profoundly.
Yanli Zhang +9 more
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Semen quality and fertility effectiveness of cloned buffalo (Bubalus bubalis) bulls
Revista Científica, 2023 In India, due to a severe shortage of elite bulls, semen available from progeny-tested bulls covers a limited breedable population of buffalo. Animal cloning has proved beneficial in making identical genetic copies in the shortest possible time to meet ...
Manoj Kumar Singh +4 more
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Disease Models & Mechanisms, 2018 Various clinical differences have been observed between patients with the FBN1 gene mutation and those with the classical Marfan phenotype. Although FBN1 knockout (KO) or dominant-negative mutant mice are widely used as an animal model for Marfan ...
Mao Chen +12 more
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IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
Nature Communications, 2020 The signals regulating the establishment and maintenance of the pluripotent epiblast in human embryos are unclear. Here, the authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a culture ...
Sissy E. Wamaitha +16 more
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