Results 21 to 30 of about 452,413 (312)
Disease Models & Mechanisms, 2018 Various clinical differences have been observed between patients with the FBN1 gene mutation and those with the classical Marfan phenotype. Although FBN1 knockout (KO) or dominant-negative mutant mice are widely used as an animal model for Marfan ...
Mao Chen +12 more
doaj +1 more source
BMC Genomics, 2020 Background DNA methylation is an epigenetic regulatory form that plays an important role in regulating the gene expression and the tissues development.. However, DNA methylation regulators involved in sheep muscle development remain unclear.
Yixuan Fan +6 more
doaj +1 more source
Activation and Inhibition of The Wnt3A Signaling Pathway in Buffalo (Bubalus bubalis) Embryonic Stem Cells: Effects of WNT3A, Bio and Dkk1 [PDF]
International Journal of Fertility and Sterility, 2015 Background This research studies the effects of activation and inhibition of Wnt3A signaling pathway in buffalo (Bubalus bubalis) embryonic stem (ES) cell-like cells.
Mohammad Zandi +7 more
doaj +1 more source
Scientific Reports, 2017 Genetically modified pigs have important roles in agriculture and biomedicine. However, genome-specific knock-in techniques in pigs are still in their infancy and optimal strategies have not been extensively investigated.
Zicong Xie +11 more
doaj +1 more source
Oct4 regulates DNA methyltransferase 1 transcription by direct binding of the regulatory element
Cellular & Molecular Biology Letters, 2018 Background The transcription factor Oct4 plays a pivotal role in the pre-implantation development of the mouse embryo. DNA methyltransferase 1 (Dnmt1) maintains the changes in DNA methylation during mammalian early embryonic development.
Fengrui Wu +6 more
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Frontiers in Cell and Developmental Biology, 2021 Down's syndrome (DS) is one of the most commonly known disorders with multiple congenital disabilities. Besides severe cognitive impairment and intellectual disability, individuals with DS also exhibit additional phenotypes of variable penetrance and ...
Yunjie Wang +18 more
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Highly efficient RNA-guided base editing in rabbit
Nature Communications, 2018 Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency ...
Zhiquan Liu +6 more
doaj +1 more source
YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development
Cell & Bioscience, 2022 Background In mammals, maternal gene products decay and zygotic genome activation (ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis.
Mingtian Deng +6 more
doaj +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source