Results 31 to 40 of about 444,108 (317)

Highly efficient RNA-guided base editing in rabbit

Nature Communications, 2018
Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency ...
Zhiquan Liu, Mao Chen, Siyu Chen, Jichao Deng, Yuning Song, Liangxue Lai, Zhanjun Li   +6 more
doaj   +1 more source

YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development

Cell & Bioscience, 2022
Background In mammals, maternal gene products decay and zygotic genome activation (ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis.
Mingtian Deng, Baobao Chen, Zifei Liu, Yongjie Wan, Dongxu Li, Yingnan Yang, Feng Wang   +6 more
doaj   +1 more source

THE IDENTIFICATION OF CHROMOSOMAL POLYMORPHISM IN ONE BREED OF IRAQI SHEEP

The Iraqi Journal of Veterinary Medicine, 1989
A chromosomal analysis of three breeds of Iraqi sheep (Karadi Arabi and Awassi) has been performed on peripheral lymphocytes. The modal chromosome number of all the three breeds was found to be (2n=54XX/54XY) for femal and male respectively.
A. A. Yasseen, M. T. Ridha-Albarzanchi, S.A.M. Alanssari A.M. Alanssari , S. G.Hussain   +3 more
doaj   +1 more source

Detrimental effects of lipopolysaccharides on maturation of bovine oocytes [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective Gram-negative bacteria lipopolysaccharide (LPS) has been reported to be associated with uterine impairment, embryonic resorption, ovarian dysfunction, and follicle retardation.
Shanjiang Zhao, Yunwei Pang, Xueming Zhao, Weihua Du, Haisheng Hao, Huabin Zhu   +5 more
doaj   +1 more source

Roles of WNT6 in Sheep Endometrial Epithelial Cell Cycle Progression and Uterine Glands Organogenesis

Veterinary Sciences, 2021
The uterus, as part of the female reproductive tract, is essential for embryo survival and in the maintenance of multiple pregnancies in domestic animals.
Xiaoxiao Gao, Xiaolei Yao, Xiaodan Li, Yaxu Liang, Zifei Liu, Zhibo Wang, Kang Li, Yingqi Li, Guomin Zhang, Feng Wang   +9 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep

Communications Biology
Anti-Müllerian Hormone (AMH), secreted by granulosa cells (GCs) of preantral follicles, regulates early-stage follicle growth by inhibiting the activation of primordial follicles.
Hui Xu, Yu Cai, Hua Yang, Chong Zhang, Wanru Liu, Binru Zhao, Feng Wang, Yanli Zhang   +7 more
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Ethics for embryos [PDF]

Journal of Medical Ethics, 2007
This paper responds to DW Brock’s technically strong case for the use of human embryonic stem cells in medical research. His main issue in this context is the question of whether it is moral to destroy viable human embryos. He offers a number of reasons to support his view that it is moral to destroy them, but his use of conceptual arguments is not ...
openaire   +3 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source